Results 111 to 120 of about 991,428 (386)

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Fingering Instability in Combustion

, 1997
A thin solid (e.g., paper), burning against an oxidizing wind, develops a fingering instability with two decoupled length scales. The spacing between fingers is determined by the P\'eclet number (ratio between advection and diffusion).
A. P. Aldushin, Elisha Moses, G. I. Sivashinsky, G. I. Sivashinsky, J. de-Ris, J. Krug, J. Zhang, M. Faraday, M. Gorman, O. Zik, Ory Zik, P. Pelce, T. Kashiwagi, Y. Zhang, Zeev Olami   +14 more
core   +1 more source

Granular Rayleigh-Taylor Instability: Experiments and Simulations [PDF]

, 2007
A granular instability driven by gravity is studied experimentally and numerically. The instability arises as grains fall in a closed Hele-Shaw cell where a layer of dense granular material is positioned above a layer of air.
Flekkoy, Eirik G., Johnsen, Oistein, Maloy, Knut Jorgen, Toussaint, Renaud, Vinningland, Jan Ludvig   +4 more
core   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Body Mass Index’s Role in Determining Maximum Mouth Opening Using the Three-Finger Index in People of Aligarh city, Uttar Pradesh

Journal of Indian Academy of Oral Medicine and Radiology
Background: Mouth opening is significant for diagnosing many clinical conditions. Therefore, it becomes essential to establish normal maximum mouth opening (MMO). Aim: To study role of BMI while evaluating MMO using three-finger index.
Pradhuman Verma, Kanika Gupta Verma, Abhinaba Das, Mohammed Najmuddin, Naseebia Khan, Muzammil Moin Ahmed   +5 more
doaj   +1 more source

Methods of Sports Genetics: dermatoglyphic analysis of human fingerprints (information 1) [PDF]

Pedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2010
The article provides data on the dermatoglyphic analysis of human fingerprints. The most informative dermatoglyphic traits of fingerprints are defined. They can be used as genetic markers to prognosticate sports endowments. The recommendations to use the
Serhiyenko L.P., Lishevskaya V.M.
doaj  

Direct Numerical Simulation of 3D Salt Fingers: From Secondary Instability to Chaotic Convection [PDF]

, 2009
The amplification and equilibration of three-dimensional salt fingers in unbounded uniform vertical gradients of temperature and salinity is modeled with a Direct Numerical Simulation in a triply periodic computational domain.
Radko, Timour, Simeonov, Julian A., Stern, Melvin E.   +2 more
core   +1 more source

Tip-splitting evolution in the idealized Saffman-Taylor problem

, 2006
We derive a formula describing the evolution of tip-splittings of Saffman-Taylor fingers in a Hele-Shaw cell, at zero surface ...
Davis P J, Eldad Bettelheim, Guervich A V, Halsey T C, Hohlov Y E, Howison S D, Jimbo M, Oded Agam, Richardson S, Siegel M   +9 more
core   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Apparatus and method of capturing an orbiting spacecraft [PDF]

, 1987
Apparatus and a method of capturing an orbiting spacecraft by attaching a grapple fixture are discussed. A probe is inserted into an opening, such as a rocket nozzle, in the spacecraft until a stop on the prove mechanism contacts the spacecraft.
Gardner, Dale A., Harwell, William D.
core   +1 more source