Results 131 to 140 of about 991,428 (386)

Targeting DNA With Fingers and TALENs

Molecular Therapy: Nucleic Acids, 2012
Researchers have long recognized that the random introduction of new DNA into the genome could result in unpredictable genetic effects due to bilateral influences between transgenic and endogenous sequences.
D. F. Carlson, S. Fahrenkrug, P. Hackett
semanticscholar   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Overcenter collet space station truss fastener [PDF]

, 1991
A quick-connect fastener is arranged with a tubular body that is arranged to be engaged against the exterior surface of a hollow attachment fitting and coincidentally aligned with an opening in the fitting.
Sheridan, Philip L.
core   +1 more source

Clubbing of the Fingers [PDF]

, 1949
W. P. U. Jackson
openalex   +1 more source

Handpicking epigenetic marks with PHD fingers

Nucleic Acids Research, 2011
Plant homeodomain (PHD) fingers have emerged as one of the largest families of epigenetic effectors capable of recognizing or ‘reading’ post-translational histone modifications and unmodified histone tails.
C. Musselman, T. Kutateladze
semanticscholar   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

An Abnormal Finger–Nose–Finger Examination [PDF]

The Journal of Pediatrics, 2022
Jennifer McDonald, Rachel Nayak
openaire   +3 more sources

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

Cellular fingers take hold

eLife, 2016
Invaginations in the membranes of embryonic cells appear to orient cell division in sea squirts.
Yukiko M Yamashita
doaj   +1 more source

Supernumerary Robotic Fingers: An Alternative Upper-Limb Prosthesis

, 2012
Conventional prosthetic devices substitute lost human limbs with mechanical proxies to enable amputees perform daily chores. We present an alternative approach that may replace or supplement traditional upper-limb prostheses by utilizing and enhancing ...
Faye Y. Wu, H. Asada
semanticscholar   +1 more source