Results 81 to 90 of about 796,554 (292)
Parameter optimization by Taguchi Methods for finishing advanced ceramic balls using a novel eccentric lapping machine [PDF]
, 2001 The final finishing process of advanced ceramic balls used in hybrid precision bearings constitutes two-thirds of the total manufacturing cost, and hence effective and economic finishing methods and processes are critical to their widespread application.
Hadfield, M, Kang, J
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Young Black America Part Two: College Entry and Completion [PDF]
, 2015 As documented in part one of this series, the high school completion rate of blacks is currently at the highest it has ever been. This second installment turns to college entry and completion.
Cherrie Bucknor
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Animal, 2012 This study aims to investigate the relative contribution of ante- and post-mortem factors to the final quality of beef. In all, 112 steers (four breed-crosses) were arranged in a 2 × 2 × 2 factorial experimental including production system, growth ...
M. Juárez +5 more
doaj +1 more source
Investigation On The Role of Cavity and Slit of Cavity Resonators to Sound Absorption Behavior [PDF]
, 2011 Slit resonator and also perforated resonator are few kind of room interior finishing. They act as sound absorbers. Gen-erally, they are constructed of at least three basic types of absorbers, such as porous, membrane and cavity compo-nents.These types of
Kristanto, Luciana, Susilo, Nugroho
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Faba beans in diets for growing-finishing pigs [PDF]
, 2003 Two experiments were carried out to study the effects of using the new faba bean (Vicia faba L.) cultivar Kontu as a domestic protein source for growing-finishing pigs.In Experiment 1,120 pigs were used with a body weight (BW)of 25–110 kg to study the ...
Alaviuhkola, Timo +3 more
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source