Results 31 to 40 of about 1,327,218 (340)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

The finite element method with penalty [PDF]

Mathematics of Computation, 1973
An application of the penalty method to the finite element method is analyzed. For a model Poisson equation with homogeneous Dirichlet boundary conditions, a variational principle with penalty is discussed. This principle leads to the solution of the Poisson equation by using functions that do not satisfy the boundary condition. The rate of convergence
openaire   +2 more sources

Cut Finite Element Methods for Linear Elasticity Problems

, 2017
We formulate a cut finite element method for linear elasticity based on higher order elements on a fixed background mesh. Key to the method is a stabilization term which provides control of the jumps in the derivatives of the finite element functions ...
Hansbo, Peter, Larson, Mats G., Larsson, Karl   +2 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Smoothed finite element method for two-dimensional elasto-plasticity

Vietnam Journal of Mechanics, 2009
This communication shows how the smoothed finite element method (SFEM) very recently proposed by G. R. Liu [14] can be extended to elasto-plasticity. The SFEM results are in excellent agreement with the finite element (FEM) and analytical results.
Stéphane Pierre Alain Bordascorres, Hung Nguyen-Dang, Quyen Phan-Phuong, Hung Nguyen-Xuan, Sundararajan Natarajan, Marc Duflot   +5 more
doaj   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

Heterogeneity of Rheumatoid Arthritis‐Associated Interstitial Lung Disease by Longitudinal Forced Vital Capacity Trajectory and Associations with Disease Outcomes

Arthritis Care &Research, Accepted Article.
Objective We aimed to identify unique disease trajectories within rheumatoid arthritis‐associated interstitial lung disease (RA‐ILD) based on longitudinal forced vital capacity (FVC) values and their associated clinical outcomes. Methods We performed a cohort study of RA‐ILD within the Veterans Health Administration from 1999‐2021. RA‐ILD patients were
Bryant R. England, Yangyuna Yang, Punyasha Roul, Tate M. Johnson, Scott M. Matson, Grant W. Cannon, Brian C. Sauer, Jeffrey R. Curtis, Joshua F. Baker, Ted R. Mikuls   +9 more
wiley   +1 more source

The effect of foot orthoses on midfoot pain and the volume of bone marrow lesions in the midfoot: a randomized mechanism of action study

Arthritis Care &Research, Accepted Article.
Objective Foot orthoses are thought to improve pain by potentially modifying internal mechanical forces. To test this, we explored whether foot orthoses can modify patterns of bone marrow lesions (BMLs) in people with midfoot pain. Methods Forty‐two people were recruited with midfoot pain and MRI‐confirmed midfoot BMLs.
Jill Halstead, Anne‐Maree Keenan, Philip G. Conaghan, Dennis McGonagle, Anthony C. Redmond   +4 more
wiley   +1 more source

Out-of-plane local mechanism analysis with finite element method

Curved and Layered Structures, 2021
The stability check of masonry structures is a debated problem in Italy that poses serious problems for its extensive use. Indeed, the danger of out of plane collapse of masonry walls, which is one of the more challenging to evaluate, is traditionally ...
Spagnuolo Roberto
doaj   +1 more source

Improvement of implicit finite element code performance in deep drawing simulations by dynamics contributions [PDF]

, 2003
To intensify the use of implicit finite element codes for solving large scale problems, the computation time of these codes has to be decreased drastically. A method is developed which decreases the computational time of implicit codes by factors.
Boogaard, A.H. van den, Huetink, J., Meinders, T.   +2 more
core   +3 more sources