Results 91 to 100 of about 12,533 (241)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Finiteness Conditions for a Group of Finite Exponent
Journal of Algebra, 1993 A periodic group \(G\) all of whose \(d\)-generator subgroups (for fixed \(d > 1\)) are solvable need not itself be solvable (Golod), and similarly for nilpotence. However if \(G\) is finite, then the solvability of every 2- generator subgroup entails the solvability of \(G\) (Thompson), and likewise for nilpotence.
openaire +2 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
On the Hierarchy of Generating Functions for Solutions of Multidimensional Difference Equations
Известия Иркутского государственного университета: Серия "Математика", 2014 In this paper we study generating functions of solutions for a difference equation with the support in a rational cone of the lattice. For Laurent series with the support in such cone we define the notion of D-finiteness and find the sufficient condition,
T.I. Nekrasova
doaj
Infrared finiteness of a thermal theory of scalar electrodynamics to all orders
European Physical Journal C: Particles and Fields, 2019 Models explaining dark matter typically include interactions with charged scalar and fermion fields. The infra-red (IR) finiteness of thermal field theories of charged fermions (fermionic QED) has been proven to all orders in perturbation theory. Here we
Pritam Sen +2 more
doaj +1 more source
Formalized MathematicsSummary We continue the formalization of field theory in Mizar. Here we prove existence and uniqueness of finite fields by constructing the splitting field of the polynomial X (p n
openaire +3 more sources
Schur finiteness and nilpotency [PDF]
, 2005 Let A be a Q-linear pseudo-Abelian rigid tensor category. A notion of finiteness due to Kimura and (independently) O'Sullivan guarantees that the ideal of numerically trivial endomorphism of an object is nilpotent.
Alessio Del Padrone +5 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
On the generic finiteness of outcome distributions for bimatrix game forms [PDF]
We provide an example of an outcome game form with two players for which there is in an open set of utilities for both players such that, in each of the associated games, the set of Nash equilibria induce a continuum of outcome distributions.
Nicolai S. Kukushkin +2 more
core