Results 121 to 130 of about 12,533 (241)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Layer-finiteness of Some Groups

Известия Иркутского государственного университета: Серия "Математика"
Infinite groups with finiteness conditions for an infinite system of subgroups are studied. Groups with a condition: the normalizer of any non-trivial finite subgroup is a layer-finite group or the normalizer of any non-trivial finite subgroup has a ...
V.I. Senashov
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finiteness matters : on finiteness related phenomena in natural languages /

, 2016
Includes bibliographical references and index.Introduction / (Kristin Melum Eide) -- Part I: Finiteness: underlying relations: Chapter 2: Finiteness and Pseudofiniteness / (Elizabeth Cowper) -- Chapter 3: The Split T Analysis / (Halldór Ármann Sigurdsson)
Eide, Kristin M.edt
core  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Anomaly cancellation and one-loop finiteness of 6D half-maximal supergravities

Journal of High Energy Physics
We suggest that the surprising one-loop finiteness of 6D half-maximal supergravities recently discovered in [1] might be related to anomaly-free SO(5, 21) G-duality symmetry in (2, 0) supergravity with 21 tensor multiplets and to anomaly-free SO(4, 20) G-
Renata Kallosh
doaj   +1 more source

Pascal e Camus: o pensamento dos limites [PDF]

Princípios, 2007
Both Pascal and Camus dared to think about the limits of men during historical moments of hegemony of rationalism. Their inquiries lead us to the contestation of important philosophical concepts, such as reason, justice and history, casting a serious ...
Emanuel R. Germano
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Universal Finiteness and Satisfiability

, 1994
) Inderpal Singh Mumick AT&T Bell Laboratories mumick@research.att.com Oded Shmueli Technion oshmu@cs.Technion.ac.il Abstract The problem of determining whether, for every extensional database, a given predicate in a given program has a finite ...
Inderpal Singh Mumick, Oded Shmueli
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