Results 291 to 300 of about 3,494,613 (395)

An Efficient Deep Learning Algorithm for Fire and Smoke Detection with Limited Data

, 2018
Abdulaziz Namozov, Young Im Cho
openalex   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

A roadmap for nature-based solutions to extreme wildfires. [PDF]

iScience
Regos A.
europepmc   +1 more source

Spatiotemporally Controlled Tumor Photodynamic/Immunotherapy Therapy Based on Upconversion Hybrid Nanosystem

Advanced Science, EarlyView.
PURH is constructed by a five‐layer upconversion nanoparticle (UCNP) surface coated with mesoporous silica, which encapsulates rose bengal (RB) within the mesoporous channels. Additionally, CpG oligonucleotides (CpG ODN) is linked to the surface, followed by the surface functionalization of hyaluronic acid (HA). This spatiotemporally controllable smart
Fang Wang, Wenfei Xu, Yuechen Liu, Shuxuan Zhu, Wenjing Liu, Shuhui Bo, Hong Sun, Bei Liu, Zhaogang Sun, Hongqian Chu   +9 more
wiley   +1 more source

A Closed‐Loop‐Capable Neural Interface Platform for Deep Brain Modulation via Integrated Non‐Viral Gene Delivery, NIR Optogenetics, and Electrophysiological Recording

Advanced Science, EarlyView.
A multifunctional, 3D porous neural interface combines non‐viral gene delivery and NIR optogenetics to enable minimally invasive, closed‐loop modulation of deep‐brain circuits. Abstract Closed‐loop neuromodulation requires precise, stable, and cell‐specific control of neural circuits with minimal invasiveness.
Chao‐Yi Chu, Zih‐Huei Chen, Chun‐Wei Liang, Pu‐Wei Wu, Wei‐Qing Guo, Bo‐Wei Chen, Chih‐Chia Huang, Ssu‐Ju Li, Ching‐Wen Chang, Yao‐Wen Liang, Shun‐An Kan, Yu‐Chun Lo, Wei‐Chen Huang, You‐Yin Chen, San‐Yuan Chen   +14 more
wiley   +1 more source

Emissions from burned structures in wildfires as significant yet unaccounted sources of US air pollution. [PDF]

Nat Commun
Tang W, Wiedinmyer C, Emmons LK, Holder AL, Uhl JH, St Denis LA, Cook M, Abolafia-Rosenzweig R, He C, Barsanti KC, Leyk S, Abatzoglou JT, Balch JK, Worden H, Levelt PF.   +14 more
europepmc   +1 more source

Analysis of the initial spray from canonical fire suppression nozzles

, 2007
Ning Ren
openalex   +1 more source

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

Advanced Science, EarlyView.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang, Zemin Jiang, Qiaoyun Yang, Hong Zheng, Minghao Wang, Chennianci Zhu, Lih‐Wen Deng, Karen Carmelina Crasta, Yih‐Cherng Liou   +8 more
wiley   +1 more source

Automated forest fire detection in ecological monitoring using enhanced deep learning networks. [PDF]

Sci Rep
Akhyar A, Lee J, Shahar N, Saputro AH, Zulkifley MA.   +4 more
europepmc   +1 more source

Osmotic Tension Asymmetry Drives Electrotactic Migration via PDLIM7‐Polarized Microfilament Coordination in Breast Cancer Cells

Advanced Science, EarlyView.
This study establishes an electric field‐induced directional migration model using fluorescence tension probes to visualize microfilament forces and intracellular osmotic pressure dynamics in the electrotactic migration of breast cancer cells. This model delineates how electromechanical interactions among membrane potential, ion channels, OP, traction ...
Ling Zhu, Zihui Zheng, Wang Li, Chenyi Shou, Ying Zhao, Lijun Zhang, Xiaoli Shi, Yunfeng Hu, Huanhuan Zhao, Huiwen Wu, Jun Guo   +10 more
wiley   +1 more source