Results 31 to 40 of about 311,854 (261)

Analysis of the impact of high temperature on the change in tensile strength of cement mortars with or without polypropylene fibres added [PDF]

Scientific Journal of the Military University of Land Forces, 2018
When evaluating concrete, its strength is the most important feature from the practical point of view. In compliance with technological requirements, the strength of concrete depends primarily on its composition, mainly on the content and strength of ...
Tomasz Drzymala, Michal Reszka
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Culture and awareness of occupational health risks amongst UK firefighters

Scientific Reports, 2023
Firefighters are exposed to toxic chemicals not only from the fire incidents they attend, but also from their contaminated station and/or personal protective equipment (PPE).
Taylor A. M. Wolffe, Louis Turrell, Andrew Robinson, Kathryn Dickens, Anna Clinton, Daniella Maritan-Thomson, Anna A. Stec   +6 more
doaj   +1 more source

Practice Recommendations for Genetic Testing of Ataxias

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Over the past decade, significant advances in genetic testing for ataxia have improved diagnostic accuracy, informed clinical trial eligibility, guided treatment decisions, and enabled cascade testing of at‐risk relatives. While guidance exists for other neurogenetic conditions, there are no standardized guidelines on genetic ...
Sharan R. Srinivasan, Amy D. Mook, Michelle Rochman, Jin Yun Helen Chen, Weiyi Mu, George R. Wilmot, Liana S. Rosenthal, Wendy R. Uhlmann   +7 more
wiley   +1 more source

Modelling of propane emissions from a tank containing a liquefied phase

MATEC Web of Conferences, 2018
During gas-phase release from the tank containing liquefied gas, the phenomenon of boiling, heat transfer from moist air to the tank, heat exchange between shell, liquid, and vapor, and mass loss can be observed.
Salamonowicz Zdzisław, Makowski Radosław   +1 more
doaj   +1 more source

Fire Size of Gasoline Pool Fires [PDF]

International Journal of Environmental Research and Public Health, 2020
This article presents an experimental investigation of the flame characteristics of the gasoline pool fire. A series of experiments with different pool sizes and mixture contents were conducted to study the combustion behavior of pool fires in atmospheric conditions.
Iveta Marková, Jozef Lauko, Linda Makovická Osvaldová, Vladimír Mózer, Jozef Svetlík, Mikuláš Monoši, Michal Orinčák   +6 more
openaire   +3 more sources

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

A Proposal for a Deflection-Based Evaluation Method for Barrel Support Brackets in the Extended Application of Fire Shutters in Logistics Facilities

Fire
This study proposes a deflection-based criterion for the assessment of barrel support brackets to ensure the structural stability of large fire shutters installed in large-scale buildings such as logistics facilities.
Jong Won Shon, Heewon Seo, Daehoi Kim, Seungjea Lee, Sungho Hong, Subin Jung   +5 more
doaj   +1 more source

Review of Safety Requirements Regarding Trading and Storing of Pyrotechnical Articles in Poland

Safety & Fire Technology, 2020
Aim: The objective of the paper was to identify and analyse relevant requirements regarding the safety of storage and usage of pyrotechnic materials, intended for civil use. The review was based on binding applicable Polish and European legal acts.
Marzena Półka , Dorota Bielesza, Anna Szajewska   +2 more
doaj   +1 more source