Results 41 to 50 of about 760,438 (300)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Fuel reduction treatments reduce modeled fire intensity in the sagebrush steppe

Ecosphere, 2022
Increased fire size and frequency coupled with annual grass invasion pose major challenges to sagebrush (Artemisia spp.) ecosystem conservation, which is currently focused on protecting sagebrush community composition and structure. A common strategy for
L. M. Ellsworth, B. A. Newingham, S. E. Shaff, C. L. Williams, E. K. Strand, M. Reeves, D. A. Pyke, E. W. Schupp, J. C. Chambers   +8 more
doaj   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Mine Fire Behavior under Different Ventilation Conditions: Real-Scale Tests and CFD Modeling

Applied Sciences, 2020
Fires in underground spaces are especially relevant due to their potential mortality. However, there is not much research in real-scale spaces done so far.
Florencio Fernández-Alaiz, Ana Maria Castañón, Fernando Gómez-Fernández, Marc Bascompta   +3 more
doaj   +1 more source

Refractory Status Epilepticus Treated With Bilateral Pulvinar Deep Brain Stimulation—A Case Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT New‐onset refractory status epilepticus (NORSE) arises without an identifiable cause or prior epilepsy history, with a 16%–27% mortality rate and significant long‐term neurological sequelae. Neuromodulation such as deep brain stimulation (DBS) targeting the anterior and centromedian thalamic nuclei has shown promise when the traditional ...
Mengxuan Tang, Amerta Bai, Felipe Rodridgues Marques Ferreira, Sandipan Pati, Thaddeus Walczak, Benjamin Miller, Oladi Bentho, Thomas Henry, Ilo Leppik, Minoo Shams, Zhiyi Sha, Zachary Sanger, Theoden I. Netoff, Thomas Lisko, Anant Naik, Robert McGovern III, Sima Patel   +16 more
wiley   +1 more source

A Wildfire Prediction Based on Fuzzy Inference System for Wireless Sensor Networks [PDF]

, 2011
The study of forest fires has been traditionally considered as an important application due to the inherent danger that this entails. This phenomenon takes place in hostile regions of difficult access and large areas.
Barbancho Concejero, Julio, González Gasull, Virginia, Larios Marín, Diego Francisco, León de Mora, Carlos, Obaidat, Mohammad S.   +4 more
core  

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Conceptual Framework of an Effective Decision Support System in Forest Fire Management

Doğal Afetler ve Çevre Dergisi, 2020
Forest fire management organizations require accurate, timely and readily available information to be successful in forest fire suppression. A sound decision support system is necessary to acquire and make this information available to fire management ...
Kadir Alperen Coşkuner, Ertuğrul Bilgili   +1 more
doaj   +1 more source

Power-law behavior reveals phase transitions in landscape controls of fire regimes [PDF]

, 2011
In low-severity fire regimes of the American West and elsewhere, landscape memory of fire events is registered in fire-scarred trees, with temporal record lengths often exceeding 200 years^1-5^.
Donald McKenzie, Maureen C. Kennedy
core   +1 more source