Results 61 to 70 of about 109,691 (309)

Muscle Control of an Extra Robotic Digit

Advanced Robotics Research, EarlyView.
This study compares muscle‐ and movement‐based control for operating a supernumerary robotic thumb. While movement control performs better in the proposed tasks, muscle‐based (EMG) control promotes broader motor learning. The results highlight the promise and challenges of using biosignals for human augmentation, offering new insights into intuitive ...
Julien Russ, Lucy Dowdall, Francesco Cenciarelli, Kitty Goodridge, Mabel Ziman, Hristo Dimitrov, Danielle Clode, Tamar R. Makin   +7 more
wiley   +1 more source

Fire risk assessment of historic urban aggregates: An application to the Yungay neighborhood in Santiago, Chile

, 2023
Concern for the preservation of historic urban centers has become an issue of international relevance, not only because of their irreplaceable cultural value, but also because of their potential positive role for the sustainable development of countries.
Palazzi, N. C., Monsalve, M., de la Llera, J. C., Baquedano Juliá, P. Baquedano, Rosas, J., Ferreira, Tiago Miguel   +5 more
core   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Current advances on the assessment and mitigation of fire risk in buildings and urban areas - First Edition

, 2023
Fire safety within residential buildings and urban environments continues to be a pressing global concern, demanding dynamic and comprehensive strategies for effective risk assessment and mitigation [...
Ferreira, Tiago Miguel, Tiago Miguel Ferreira   +1 more
core   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Fire risk assessment – from property to people

, 2014
Two studies sponsored by the Nottinghamshire Fire and Rescue Service, one into the assessment and management of risk, and the other on effective communication, picked up the top two prizes in this year’s Fire Related Research and Developments ...
Murphy, P, Greenhalgh, K
core  

Fire Risk Assessment and Safety Management in Buildings and Urban Spaces—A New Section of Fire Journal

, 2022
It is a great pleasure to assume the role of Editor-in-Chief for the “Fire Risk Assessment and Safety Management in Buildings and Urban Spaces” Section of Fire (https://www [...
Tiago Miguel Ferreira, Ferreira, Tiago Miguel   +1 more
core   +1 more source

Fire Risk Assessment: A Systematic Review of the Methodology and Functional Areas

Iranian Journal of Health, Safety and Environment, 2017
Fire is a physical and social phenomenon that affects both individuals and the environment. Fire risk assessment is a critical part of a fire prevention program. In this process, the fire risk associated with the possibility of occurrence and severity of
Parisa Moshashaei, Seyed Shamseddin Alizadeh   +1 more
doaj  

Fire Hazard Risk Grading of Timber Architectural Complexes Based on Fire Spreading Characteristics

Buildings
Fire spread between buildings is the primary cause of extensive fire damage in traditional village timber structure clusters. Accurately assessing fire spread risk is crucial for the preservation of these architectural ensembles.
Chong Wang, Zhigang Song, Jian Zhang, Lijiao Liu, Feiyang Zheng, Siqi Cao   +5 more
doaj   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source