Results 101 to 110 of about 136,513 (302)

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Semi-natural test methods to evaluate fire safety of wall claddings: Update

MATEC Web of Conferences, 2016
There are a number of test methods worldwide to evaluate fire safety of facades. An overview of available test methods implemented in fire safety codes was presented at the 1st Conference of Fire Safety of Facades in 2013.
Smolka Miroslav, Anselmi Eleonora, Crimi Tony, Madec Bruce Le, Móder István Ferenc, Park Kye Won, Rupp Roman, Yoo Yong-Ho, Yoshioka Hideki   +8 more
doaj   +1 more source

The Reaction to Fire Tests for Natural Thermal Insulation of Hemp Material Modified by Fire Retardant Ohnostop Special

Communications, 2015
The scope of the paper is the experiment focused on testing and evaluating the fire protection of fire retardant modification of combustible material by means of experimental scientific method of the reaction to fire test.
Adelaida Fanfarova, Ladislav Maris, Anton Osvald, Esko Mikkola   +3 more
doaj   +1 more source

Test of war surplus-air foam conducted at Fire station No. 3, 526 E Anaheim.

, 1951
Firefighters spray fire retarding foam onto the street in front of station as part of test.Categorized under ...

core  

A novel method to evaluate fire test performance of water mist and water spray total compartment protection

, 2013
Traditionally, the only parameter used to measure the performance of total compartment (i.e. total flooding) water mist or water spray systems during fire testing has been the time to extinguishment.
Arvidson, Magnus,
core   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Large Scale Tunnel Fire Tests with Large Droplet Water-Based Fixed Fire Fighting System

, 2016
This paper presents the main results of six large scale fixed fire fighting system tests that were carried out in the Runehamar tunnel in September 2013. It describes the background and the performance of the system.
Ingason, Haukur,, Appel, Glenn,, Becker, Conny,, Lundström, Ulf,, Li, Ying Zhen,   +4 more
core   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

A new fire performance test for cavity wall insulation

MATEC Web of Conferences, 2016
Cavity walls containing combustible insulation present an increased risk for fire propagation in a confined, concealed space. Damage to the building resulting from ignition of combustible insulation can be extensive; especially so, in the absence of ...
Jamison Kristin L.T., Boardman Daniel A.
doaj   +1 more source