Results 31 to 40 of about 1,192,421 (282)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Research on Generation and Quality Evaluation of Earthquake Emergency Language Service Contingency Plan Based on Chain-of-Thought Prompt Engineering for LLMs

Inventions
China frequently experiences natural disasters, making emergency language services a key link in information transmission, cross-lingual communication, and resource coordination during disaster relief.
Wenyan Zhang, Kai Zhang, Ti Li, Wenhua Deng   +3 more
doaj   +1 more source

The Effect of Environmental Moisture Conditions on the Calculated Incident Radiant Heat Flux by Plate Thermometers

Journal of Open Innovation: Technology, Market and Complexity, 2020
This study investigates the effect of environmental moisture conditions on the calculated incident radiant heat flux (irradiance) by plate thermometers (PT).
Lahiru Jayathunga-Mudiyanselage, Haejun Park, Virginia Charter, Rob Agnew   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Aromatic vs. Aliphatic Hyperbranched Polyphosphoesters as Flame Retardants in Epoxy Resins

Molecules, 2019
The current trend for future flame retardants (FRs) goes to novel efficient halogen-free materials, due to the ban of several halogenated FRs. Among the most promising alternatives are phosphorus-based FRs, and of those, polymeric materials with complex ...
Jens C. Markwart, Alexander Battig, Maria M. Velencoso, Dennis Pollok, Bernhard Schartel, Frederik R. Wurm   +5 more
doaj   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Testing of aluminium composite panels in a cone calorimeter: A new specimen preparation method

Polymer Testing, 2022
Fire testing data consistency and repeatability are essential for regulatory scrutiny, product development, and fire modelling of the lightweight cladding system.
Md Delwar Hossain, Swapan Saha, Md Kamrul Hassan, Anthony Chun Yin Yuen, Cheng Wang, Waseem Hittini, Laurel George, Richard Wuhrer   +7 more
doaj   +1 more source

Expanded Parameters in the Self-Organized Critical Forest Fire Model [PDF]

, 2016
The forest fire model has frequently been used as a way to test the theory of Self-Organized Criticality, which is a model of complexity. The model analyzes commonalities in randomly generated forest fires using a computer simulation. In previous models,
Self, Riley M.
core   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source