Results 61 to 70 of about 868 (220)
Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress
Interdisciplinary Medicine, EarlyView.This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu +13 more
wiley +1 more source
Plasma fireball sheath dynamics: a brief review and meta-analysis
Discover SpaceWe present a progressive overview of diverse plasma fireball sheath (PFS) structures, sheath-induced collective phenomena, and associated instability excitation processes, illustratively.
Subham Dutta +2 more
doaj +1 more source
Interdisciplinary Medicine, EarlyView.This review highlights recent advances in mitochondria‐targeted nanomedicine for cancer therapy. It summarizes key targeting strategies and delineates four principal therapeutic mechanisms: oxidative stress–induced mitochondrial dysfunction, disruption of energy metabolism, direct mitochondrial damage, and induction of immunogenic cell death.
Linfeng Xiao +7 more
wiley +1 more source
Journal of Dental Education, EarlyView.ABSTRACT Biochemistry forms the foundation for understanding biomolecules and molecular processes crucial to dental and oral biology. However, it is often perceived as a challenging subject for dental students with diverse educational backgrounds. Analogies are a pedagogical tool that helps explain new and abstract concepts in biochemistry.
Ulysses Tsz Fung Lam, Yun Chau Long
wiley +1 more source
Height of a Leonid Fireball [PDF]
Monthly Notices of the Royal Astronomical Society, 1888 n ...
openaire +1 more source
Mapping Multi‐Stakeholder Engagement: A Q Methodology in a Regional Project Management Scenario
Strategic Change, EarlyView.ABSTRACT Research on project management describes the essence of projects involving multiple stakeholders, stressing the value derived from diverse work practices. However, this underestimates issues of counterproductive disagreements associated with diverse groups participating in a project.
Sheng Hu, Amon Simba
wiley +1 more source
Strategic Change, EarlyView.ABSTRACT This paper considers the tensions between different organizational strategic decision‐making approaches at various levels of uncertainty. Of particular focus are the mechanisms for defaulting to lower uncertainty, from the Cynefin framework's unordered chaotic and complex domains to the more ordered complicated and obvious domains.
Richard J. Logan +3 more
wiley +1 more source
Land Degradation &Development, EarlyView.ABSTRACT In developing economies, the agricultural sector enhances national food security, employment, and economic prosperity, while it is also closely linked to the ecological system. International trade, technological innovations, and fertilizer use are modern inputs to increase output; however, their unsustainable use leads to environmental ...
Jie Yue, Yichen Yao, Bin Gong
wiley +1 more source
Land Degradation &Development, EarlyView.ABSTRACT Land use conflicts (LUCs) significantly impact regional food security and ecological security. Identifying LUCs helps cut down ecological risks. This study focuses on the Yangtze River Middle Reaches Megalopolis (YRMRM) as a case, employing a landscape pattern approach to construct a land use conflict measurement model.
Xufeng Cui +5 more
wiley +1 more source