Results 151 to 160 of about 91,662 (198)

Clinicopathological characteristics of patients with inoperable non‐small cell lung cancer harboring circulating NRF2 pathway mutations

open access: yesThe Journal of Pathology, EarlyView.
Abstract Lung cancer is the leading cause of global cancer‐related morbidity and mortality, with tobacco smoking as its strongest risk factor. Nuclear factor erythroid 2‐related factor 2 (NRF2) is a redox‐regulated transcription factor frequently dysregulated in non‐small cell lung cancer (NSCLC), leading to aggressive disease and resistance to therapy.
Jouni Härkönen   +14 more
wiley   +1 more source

Pharmacological Inhibition of APT2 by Solasonine Promotes Ferroptosis Through Palmitoylation Modulation in Gallbladder Cancer

open access: yesPhytotherapy Research, EarlyView.
Schematic illustration of SS‐induced ferroptosis through targeting APT2‐mediated STAT3 palmitoylation in GBC cells. ABSTRACT Gallbladder cancer (GBC), the most prevalent and lethal biliary tract malignancy, lacks effective therapeutic strategies. Solasonine (SS), a bioactive steroidal alkaloid derived from Solanum nigrum L, exhibits antitumor activity ...
Liu‐qing Shi   +12 more
wiley   +1 more source

Inhibition of PHF1 promotes ferroptosis via IRES‐dependent Snail translation regulation in pancreatic ductal adenocarcinoma

open access: yesVIEW, EarlyView.
PHF1 is a known epigenetic regulator involved in transcriptional silencing in cancer. In this study, we identified PHF1 as an oncogene that promotes PDAC progression and demonstrated that its inhibition induces ferroptosis. Mechanistically, PHF1 physically interacts with the FBL/NOP56/NOP58 snoRNP complex to enhance the IRES‐dependent translation of ...
Yujiao Xie   +9 more
wiley   +1 more source

Cockayne syndrome mutation in XPG activate the integrated stress response. [PDF]

open access: yesHum Genet
Zhang D   +8 more
europepmc   +1 more source

AML‐Net: Attention‐based multi‐scale lightweight model for brain tumour segmentation in internet of medical things

open access: yesCAAI Transactions on Intelligence Technology, EarlyView.
Abstract Brain tumour segmentation employing MRI images is important for disease diagnosis, monitoring, and treatment planning. Till now, many encoder‐decoder architectures have been developed for this purpose, with U‐Net being the most extensively utilised. However, these architectures require a lot of parameters to train and have a semantic gap. Some
Muhammad Zeeshan Aslam   +3 more
wiley   +1 more source

Bio‐Inspired Optimisation Methods Applied to Low Carbon Power and Energy Problems: A Survey

open access: yesCAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Bio‐inspired optimisation methods have been widely applied to complex real‐world problems, particularly in low‐carbon power and energy systems, where optimisation tasks often involve high‐dimensional, constrained and mixed‐integer characteristics.
Tianyu Hu   +4 more
wiley   +1 more source

Structural Feature Selection in Common Spatial Patterns Using Adaptive Sparse Group Lasso

open access: yesCAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT With the advancement of brain–computer interfaces (BCI), motor imagery (MI) electroencephalogram (EEG) decoding can greatly benefit from spatial filtering features derived from common spatial patterns (CSP). However, CSP‐based features often exhibit high redundancy and intersubject variability.
Yadi Wang   +4 more
wiley   +1 more source

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