Results 171 to 180 of about 91,662 (198)

Downregulation of SLC40A1 leads to iron accumulation in fibrotic lung fibroblasts. [PDF]

Respir Res
Dang Q, Huang C, Liang Y, Surendran A, Muthiah D, Vaddadi K, Hewawasam S, Mills TW, Liu L.   +8 more
europepmc   +1 more source

Development of a functional assay for the characterisation of SMAD4 variants from the French haemorrhagic hereditary telangiectasia cohort. [PDF]

J Med Genet
Despas L, Vialet L, Tusseau M, Azemard V, Beurier-Soulat L, Al Tabosh T, Auboiroux C, Parrot A, Blivet S, Le Guillou Horn XM, Lesca G, Dufernez F, Coulet F, Richardot C, Macias M, Giraud S, Guilhem A, Dupuis-Girod S, Bailly S, Desroches-Castan A.   +19 more
europepmc   +1 more source

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, EarlyView.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source

Correction: Emergent periodicity in the collective synchronous flashing of fireflies.

Elife
Sarfati R, Joshi K, Martin O, Hayes JC, Iyer-Biswas S, Peleg O.   +5 more
europepmc   +1 more source

mRNA-based SARS-CoV-2 vaccines: intracellular processing and aggregation of the encoded spike protein as a mechanistic contributor to cardiac cellular stress. [PDF]

Front Immunol
Schreckenberg R, Woitasky N, Itani N, Czech L, Windhorst AC, Juchem M, Bär C, Thum T, Ferdinandy P, Schulz R.   +9 more
europepmc   +1 more source

Phosphatase PPP1CC Regulates the First Lineage Segregation by GAS5 in Mouse Preimplantation Embryos

Cell Proliferation, EarlyView.
Subcortical GAS5 directs PPP1CC phosphatase spatiotemporal positioning during mouse morula‐blastocyst transition, controlling YAP dephosphorylation to drive first embryonic lineage specification. ABSTRACT The transcriptional effector of the Hippo signalling pathway, YAP, regulates the first lineage specification in mouse preimplantation embryos ...
Jianwu Wang, Yan Zhang, Laijin Wu, Hongshuang Xie, Guang Yang, Yiwei Zhang, Cheng Huang, Shanyi Chou, Xuehan Li, Zhonghua Liu, Jiaqiang Wang   +10 more
wiley   +1 more source

Firefly algorithm with multiple learning ability based on gender difference. [PDF]

Sci Rep
Zhang W, Jiao C, Zhou Q.
europepmc   +1 more source

Lactate Accelerates Early Angiogenesis and Bone Regeneration Through Macrophage M1 Polarisation

Cell Proliferation, EarlyView.
During the early stage of bone defect healing, lactate accumulates and contributes to increasing NOD1 expression by stabilising HIF1α that in turn triggers a calcium influx, which ultimately polarises macrophages towards the M1 phenotype and accelerates vascularisation of endothelial cells.
Lulu Liu, Danning Ma, Jia Song, Boon Chin Heng, Ying Huang, Xuehui Zhang, Mingming Xu, Yan Wei, Tai Wei, Jinqi Wei, Xuliang Deng   +10 more
wiley   +1 more source

The Source of Firefly Chemical Defenses: Endogenous Biosynthesis of Lucibufagins from Cholesterol. [PDF]

ACS Omega
Smedley SR, Medeiros KK, Gaber M, Howells NR, Posner DA, Rahim FU, Deyrup LD, Deyrup ST.   +7 more
europepmc   +1 more source

BOLL‐Containing Aggregates Mediate the Translational Regulation During Human Oogenesis

Cell Proliferation, EarlyView.
This work elucidates that BOLL‐containing aggregate‐mediated translational control is essential for human oogenesis. These aggregates recruit PABPC1 and FXR1 to activate the translation of U‐rich mRNAs encoding cell cycle proteins, thereby ensuring successful meiotic progression.
Ying Li, Lingya Mao, Boyuan Liang, Longxin Xie, Wenpei Xiang, Kehkooi Kee   +5 more
wiley   +1 more source