Results 181 to 190 of about 155,939 (286)

Development of a functional assay for the characterisation of <i>SMAD4</i> variants from the French haemorrhagic hereditary telangiectasia cohort. [PDF]

J Med Genet
Despas L, Vialet L, Tusseau M, Azemard V, Beurier-Soulat L, Al Tabosh T, Auboiroux C, Parrot A, Blivet S, Le Guillou Horn XM, Lesca G, Dufernez F, Coulet F, Richardot C, Macias M, Giraud S, Guilhem A, Dupuis-Girod S, Bailly S, Desroches-Castan A.   +19 more
europepmc   +1 more source

Bioinspired, Guanidinium, and Indole Modified Poly(glycidyl ether)s as Highly Efficient Vectors for Polyplex‐Mediated Gene Delivery

Macromolecular Rapid Communications, EarlyView.
Guanidinium‐ and indole‐functionalized poly(glycidyl ether)s were developed as non‐viral gene delivery vectors with tunable hydrophilic–hydrophobic balance. All polymers formed stable DNA polyplexes, while moderate indole content yielded the highest transfection efficiency at low N/P ratios.
Markus Kötzsche, Andreas Dzierza, Lennert Sölter, Jan Egger, Kjell Cornelis, Andreas Stihl, Felix H. Schacher, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

Engineering and comparison of cas12a-based genome editing systems in plants. [PDF]

Plant J
Bircheneder M, Parniske M.
europepmc   +1 more source

A pathway for low zinc homeostasis that is conserved in animals and acts in parallel to the pathway for high zinc homeostasis [PDF]

, 2017
Dietrich, Nicholas, Kornfeld, Kerry, Schneider, Daniel L   +2 more
core   +2 more sources

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Improving retinal vessel assessment precision by integrating deep learning with interactive editing and graphical modeling. [PDF]

Sci Rep
Go S, Chae J, Kim U, Lim J, Kim J, Hogg S, Trucco E, Park SJ, Lee S.   +8 more
europepmc   +1 more source

Pharmacological Inhibition of APT2 by Solasonine Promotes Ferroptosis Through Palmitoylation Modulation in Gallbladder Cancer

Phytotherapy Research, EarlyView.
Schematic illustration of SS‐induced ferroptosis through targeting APT2‐mediated STAT3 palmitoylation in GBC cells. ABSTRACT Gallbladder cancer (GBC), the most prevalent and lethal biliary tract malignancy, lacks effective therapeutic strategies. Solasonine (SS), a bioactive steroidal alkaloid derived from Solanum nigrum L, exhibits antitumor activity ...
Liu‐qing Shi, Jing‐wei Zhao, Jia‐yun Zhu, Cheng Zhao, Zi‐yi Yang, Li‐jia Pan, Ben Ma, Zheng‐yu Chen, Zi‐ying Wang, Chun‐jie Li, Shi‐lei Liu, Jia‐wei Mei, Ping Dong   +12 more
wiley   +1 more source

Involvement of a tick-borne orthomyxovirus matrix protein in vRNP nuclear export. [PDF]

J Virol
Swenson VA, Hemsath J, Yousaf I, Weisend C, Barry MA, Ebihara H, Yamaoka S.   +6 more
europepmc   +1 more source

Launch support: Managing complementor bottlenecks in the disruptive innovation of small satellites

Strategic Management Journal, EarlyView.
Abstract Research Summary Through both qualitative and quantitative analyses of large‐rocket providers' support for small‐satellite manufacturers before the emergence of small rockets, we examine how disruptors to an incumbent ecosystem gain support from complementors of the incumbent technology.
Yue Song, Yue Maggie Zhou, Xiaoping Zhao
wiley   +1 more source

Emergence of mammalian-adaptive PB2 mutations enhances polymerase activity and pathogenicity of cattle-derived H5N1 influenza A virus. [PDF]

Nat Commun
Zhang L, Lai Y, Cui Y, Yang Q, Shao Y, Ding S, Wang H, Wang L, Gao GF, Deng T.   +9 more
europepmc   +1 more source