Results 111 to 120 of about 34,802 (225)

RNA binding protein ZFP36L1 promotes ferroptosis in chronic rhinosinusitis by destabilizing CAMK2A mRNA and impairing mitochondrial quality control

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
This graphical abstract illustrates the novel ZFP36L1–CAMK2A regulatory axis in chronic rhinosinusitis (CRS) pathogenesis: 1. Molecular initiation: In nasal epithelial cells, the RNA‐binding protein ZFP36L1 (upregulated in CRS) directly binds to AU‐rich elements (AREs) in the 3′‐untranslated region (3′‐UTR) of CAMK2A mRNA, promoting its degradation and
Jiayi Xiong, Shihan Zhang, Chunhua Li, Yufeng Ai, Xinru Liu, Yuxiang Liu, Hongbing Liu   +6 more
wiley   +1 more source

HTLV‐1 Tax Reshapes the DNA‐Binding Pattern of Transcription Factor IRF4 and Disrupts Host Gene Regulation

Cancer Science, Volume 117, Issue 5, Page 1497-1509, May 2026.
Proteomic mapping of Tax complexes in HTLV‐1–infected T‐cells identified IRF4 as a Tax interactor. Chromatin profiling showed Tax reprograms IRF4 occupancy with H3K27ac gains at super‐enhancers; Tax–IRF4 co‐expression altered chromatin accessibility and transcription, and ATL‐associated IRF4 mutants partially phenocopied these changes. ABSTRACT Human T‐
Shu Tosaka, Jun Mizuike, Motomu Yano, Kaoru Uchimaru, Makoto Yamagishi   +4 more
wiley   +1 more source

Genetic Basis of UV Bullseye Size Variations in Turnip Rape (Brassica rapa subsp. oleifera)

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3189-3200, May 2026.
ABSTRACT Floral ultraviolet (UV) patterns are visible to bee pollinators and can affect crop yields by impacting pollinator visitation. However, the mechanisms underlying the intraspecific variations of UV bullseye size remain largely unknown. We analyse the ecological consequences and genetic basis of floral UV bullseye size variation in an important ...
Zhi‐Li Zhou, Yu Zhang, Li‐Ling Jiang, An‐Ning Li, Guo‐Peng Zhang, Ming‐Liu Yang, Zhi‐Qiang Zhang, Dong‐Rui Jia, Bin Tian, Xu‐Dong Sun, Yong‐Ping Yang, Yuan‐Wen Duan   +11 more
wiley   +1 more source

Intelligent Selection of Machining Parameters in Multipass Turnings Using Firefly Algorithm

Modelling and Simulation in Engineering, 2014
Determination of optimal cutting parameters is one of the most important elements in any process planning of metal parts. In this paper, a new optimization technique, firefly algorithm, is used for determining the machining parameters in a multipass ...
Abderrahim Belloufi, Mekki Assas, Imane Rezgui   +2 more
doaj   +1 more source

A Computational Modeling of ADLumin Chemiluminescence: Oxygenation and Dioxetanone Formation

Journal of Computational Chemistry, Volume 47, Issue 11, 30 April 2026.
Chemiluminescent ADLumin molecules were studied using DFT to investigate their mechanisms of oxygenation and dioxetanone formation. Different oxygenation sites were explored for initiating competing reaction pathways that converge to the same 1,2‐dioxetanone intermediate.
Carly Wickizer, Chance Lander, Zheng Pei, Wai Tak Yip, Chongzhao Ran, Yihan Shao   +5 more
wiley   +1 more source

BPM31510 Increases the CoQ Pool in Chemically Induced CoQ‐Deficient Cells, CoQ‐Deficient Patient Fibroblasts, and in Metabolically Active Murine Tissues

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Graphical abstract illustrating the in vitro and in vivo experimental workflow used to compare BPM31510, a nanoliposomal formulation of oxidized CoQ10, with conventional CoQ10. Chemically induced CoQ‐deficient SH‐SY5Y cells, CoQ‐deficient patient fibroblasts, and C57BL/6J mice receiving oral CoQ10 or intraperitoneal BPM31510 were subjected to plasma ...
Juan J. Aristizabal‐Henao, Sarah R. Wessel, Sylwia A. Stopka, Srada Karmacharya, Devon Van Cura, Alba Pesini, Kelsey R. Nickerson, Kashni Grover, Oksana Zavidij, Archna Ravi, Andressa L. Mota, Kenneth M. Rosen, Maria‐Dorothea Nastke, Megan K. Cox, Niven R. Narain, Vijay Modur, Catarina M. Quinzii, Stephane Gesta, Michael A. Kiebish   +18 more
wiley   +1 more source

TESS Data Release Notes: Sector 18 DR25 [PDF]

This release note discusses the science data products produced by the Science Processing Operations Center at Ames Research Center from Sector 18 observations made with the TESS spacecraft and cameras as a means to document instrument performance and ...
Burke, Christopher J., Caldwell, Douglas A., Doty, John, Fausnaugh, Michael M., Jenkins, Jon M., Smith, Jeffrey C., Ting, Eric B., Twicken, Joseph D., Vanderspek, Roland, Villesenor, Joel S.   +9 more
core   +1 more source

Flavonoid Oxime Carbamate Derivatives: Reversal of Multidrug Resistance in Cancer Cells

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A set of 23 new flavonoid oxime carbamates was synthesized and evaluated as multidrug resistance (MDR) reversers in ABCB1‐transfected mouse lymphoma cells. All derivatives strongly inhibited P‐glycoprotein (P‐gp) efflux activity in a transport assay, while most selected compounds behaved as ATPase inhibitors. In drug combination assays, they interacted
Filipa Barbosa, Gabriella Spengler, Noémi Bózsity, Nikoletta Szemerédi, István Zupkó, Maria‐José U. Ferreira   +5 more
wiley   +1 more source

Elephant Search with Deep Learning for Microarray Data Analysis

, 2017
Even though there is a plethora of research in Microarray gene expression data analysis, still, it poses challenges for researchers to effectively and efficiently analyze the large yet complex expression of genes.
Panda, Mrutyunjaya
core  

Dynamic Replication based on Firefly Algorithm in Data Grid [PDF]

Journal of Advances in Computer Engineering and Technology, 2017
In data grid, using reservation is accepted to provide scheduling and service quality. Users need to have an access to the stored data in geographical environment, which can be solved by using replication, and an action taken to reach certainty.
mehdi Sadeghzadeh
doaj