Results 61 to 70 of about 34,802 (225)
Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang +11 more
wiley +1 more source
A New Modified Firefly Algorithm for Optimizing a Supply Chain Network Problem
Applied Sciences, 2018 Firefly algorithm is among the nature-inspired optimization algorithms. The standard firefly algorithm has been successfully applied to many engineering problems. However, this algorithm might be stuck in stagnation (the solutions do not enhance anymore)
Ashkan Memari +3 more
doaj +1 more source
Speeding Up MCMC by Efficient Data Subsampling
, 2018 We propose Subsampling MCMC, a Markov Chain Monte Carlo (MCMC) framework where the likelihood function for $n$ observations is estimated from a random subset of $m$ observations.
Kohn, Robert +3 more
core +2 more sources
The 5 ' untranslated region of protein kinase C delta directs translation by an internal ribosome entry segment that is most active in densely growing cells and during apoptosis. [PDF]
, 2002 Protein kinase Cdelta (PKCdelta) is a member of the PKC family of phospholipid-dependent serine/threonine kinases and is involved in cell proliferation, apoptosis, and differentiation.
Morrish, B.C., Rumsby, M.G.
core +2 more sources
Advanced Science, EarlyView.This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu +18 more
wiley +1 more source
Journal of Intelligent Systems with Applications, 2018 In this study, the advantages of the parallel compution paradigms are utilized in a recent optimization algorithm, firefly algorithm. In the proposed implementation, the population is divided into subpopulations and each subpopulation is run on a different processing node.
BAŞTÜRK, Alper, AKAY, Rüştü
openaire +2 more sources
Advanced Science, EarlyView.In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu +18 more
wiley +1 more source
Improved light extraction in the bioluminescent lantern of a Photuris firefly (Lampyridae)
, 2013 A common problem of light sources emitting from an homogeneous high-refractive index medium into air is the loss of photons by total internal reflection. Bioluminescent organisms, as well as artificial devices, have to face this problem.
Bay, Annick +3 more
core +3 more sources
An improved discrete bat algorithm for symmetric and asymmetric traveling salesman problems [PDF]
, 2015 Bat algorithm is a population metaheuristic proposed in 2010 which is based on the echolocation or bio-sonar characteristics of microbats. Since its first implementation, the bat algorithm has been used in a wide range of fields.
Carballedo, Roberto +4 more
core +2 more sources
Advanced Science, EarlyView.Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji +10 more
wiley +1 more source