Results 301 to 310 of about 1,517,963 (349)

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

open access: yesAdvanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra   +23 more
wiley   +1 more source

Statistical dynamics of wildfire burned area from cellular-automata simulators. [PDF]

open access: yesSci Rep
Sahila A   +5 more
europepmc   +1 more source

Spatiotemporally Controlled Tumor Photodynamic/Immunotherapy Therapy Based on Upconversion Hybrid Nanosystem

open access: yesAdvanced Science, EarlyView.
PURH is constructed by a five‐layer upconversion nanoparticle (UCNP) surface coated with mesoporous silica, which encapsulates rose bengal (RB) within the mesoporous channels. Additionally, CpG oligonucleotides (CpG ODN) is linked to the surface, followed by the surface functionalization of hyaluronic acid (HA). This spatiotemporally controllable smart
Fang Wang   +9 more
wiley   +1 more source

A Closed‐Loop‐Capable Neural Interface Platform for Deep Brain Modulation via Integrated Non‐Viral Gene Delivery, NIR Optogenetics, and Electrophysiological Recording

open access: yesAdvanced Science, EarlyView.
A multifunctional, 3D porous neural interface combines non‐viral gene delivery and NIR optogenetics to enable minimally invasive, closed‐loop modulation of deep‐brain circuits. Abstract Closed‐loop neuromodulation requires precise, stable, and cell‐specific control of neural circuits with minimal invasiveness.
Chao‐Yi Chu   +14 more
wiley   +1 more source

Rising rates of wildfire building destruction in the conterminous United States. [PDF]

open access: yesProc Natl Acad Sci U S A
Carlson AR   +9 more
europepmc   +1 more source

Osmotic Tension Asymmetry Drives Electrotactic Migration via PDLIM7‐Polarized Microfilament Coordination in Breast Cancer Cells

open access: yesAdvanced Science, EarlyView.
This study establishes an electric field‐induced directional migration model using fluorescence tension probes to visualize microfilament forces and intracellular osmotic pressure dynamics in the electrotactic migration of breast cancer cells. This model delineates how electromechanical interactions among membrane potential, ion channels, OP, traction ...
Ling Zhu   +10 more
wiley   +1 more source

The 2025 Los Angeles Wildfires and Outpatient Acute Health Care Utilization.

open access: yesJAMA Health Forum
Casey JA   +11 more
europepmc   +1 more source

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