Results 221 to 230 of about 88,897 (264)

A Noninvasive Approach to Study Localized Forces in 3D Epithelia

Advanced Materials, EarlyView.
Epithelial morphogenesis depends on dynamic mechanical coupling between adhesion complexes and the cytoskeleton, yet its regulation in polarized 3D tissues remains elusive. We developed a noninvasive strategy using cell‐like elastic microbeads to quantify local forces in intact epithelia.
Niels Gouirand, Muhamet Ibrahimi, Claire Valotteau, Brice Lecouffe, André Le Bivic, Dominique Massey‐Harroche, Felix Rico, Matthias Merkel, Delphine Delacour, Elsa Bazellières   +9 more
wiley   +1 more source

Plasmonically Enhanced Microarray Immunoassay for High‐Sensitivity Monitoring of Heart Failure

Advanced Materials, EarlyView.
A novel plasmonically enhanced PE‐D4 assay combines nanopatch antennas with a microarray immunoassay for the detection of heart failure biomarkers NT‐proBNP, NGAL, and galectin‐3 in complex biological samples. Plasmonic amplification substantially enhances fluorescence signals, enabling sensitive biomarker quantification with a low‐cost smartphone ...
Daria Semeniak, Deniz Acil, Jason Liu, Daniela F. Cruz, Cassio M. Fontes, Chengyang Li, Brooke E. Silverstein, G. Michael Felker, Angus M. Hucknall, Maiken H. Mikkelsen, Ashutosh Chilkoti   +10 more
wiley   +1 more source

An Engineered Thio‐Amino Polymer Achieves Potent, Safe, and Broad Cell Type Delivery in the Lung Mapped by Spatial Transcriptomics

Advanced Materials, EarlyView.
Synthesis and screening of a polymer library produced a versatile and inhalable mRNA vehicle for the lungs (P81). Compared to a published LNP, P81 provides increased delivery efficacy, achieving widespread expression in broad cell types, with no toxicity.
Pramodkumar EK, Younghun Jung, Elex S. Rose, Jae Yeon Joo, James R. Rose, José A. F. Assumpção, Hyeyoon Jeong, Lorena C. S. Chaves, Blake Andrew Miller, João Paulo Pera Mendes, Hannah E. Peck, Charmy J. Patel, Loren E. Sasser, Heather Pathak, Varun V. Mosur, Jaehyeon Hwang, Guilherme de Oliveira Lopes, Merrilee Thoresen, Santiago Cornejo, Peres Badial, Alicia Olivier, Amelia R. Woolums, Samuele Stazzoni, Noemi Manganaro, Eleonora Nencini, Giulio Pierleoni, Emanuele Andreano, Rino Rappuoli, Nichole Orr‐Burks, Sarah R. Hosking, Nicholas S. Heaton, Eric R. Lafontaine, Robert J. Hogan, Francois Villinger, Daryll Vanover, Chiara Zurla, Philip J. Santangelo   +36 more
wiley   +1 more source

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Within-Firm Pay Inequality and Firm Performance

2022
Using a unique dataset with administrative information on over two million matched employeremployee-year observations in Italy over the 1994-2000 period, we examine the causal effect of a quasi-exogenous shock to within-firm pay inequality on firm performance.
Antonio De Vito, Juan-Pedro Gomez
openaire   +2 more sources

Firm Age and Performance [PDF]

, 2009
As firms grow older, their profitability seems to decline. We first document this phenomenon and show that it is very robust. Then we offer two non-exclusive explanations of why firms may age. First, corporate aging could reflect a cementation of organizational rigidities over time. Consistent with that, costs rise, growth slows, assets become obsolete,
Loderer, Claudio, Waelchli, Urs
openaire   +2 more sources

Unions, Training, and Firm Performance [PDF]

, 2008
The present paper uses a combination of workplace and linked employee-workplace data from the 1998 Workplace Employee Relations Survey and the 2004 Workplace Employment Relations Survey to examine the impact of unions on training incidence, training intensity/coverage, and training duration.
John T. Addison, Clive R. Belfield
openaire   +4 more sources

IT alignment and firm performance in small manufacturing firms

The Journal of Strategic Information Systems, 2002
The concept of IT alignment has been discussed in the literature, but almost always in the context of large firms. Similarly, attempts to measure alignment and relate it to performance have been made, but primarily based on work in larger firms. This study focused on measuring the alignment of business strategy and IT strategy (ITS) among small UK ...
Paul B. Cragg, Malcolm King, Husnayati Hussin   +2 more
openaire   +1 more source

MARKET PERFORMANCE WITH MULTIPRODUCT FIRMS* [PDF]

Journal of Industrial Economics, 2006
We revisit the fundamental issue of market provision of variety associated with Chamberlin, Spence, and Dixit-Stiglitz when firms sell multiple products. Both products and firms are (horizontally) differentiated. We propose a general nested demand framework where consumers first decide upon a firm then which variant to buy and how much (the nested CES ...
Simon P. Anderson, André de Palma
openaire   +1 more source

Technical Debt and Firm Performance

Management Science, 2021
Technical debt refers to the design, development, and implementation shortcuts taken by firms when deploying accounting information systems. Prior system-level studies have shown that such shortcuts decrease the reliability of systems and increase the long-term system maintenance obligations.
Rajiv Banker, Yi Liang, Narayan Ramasubbu   +2 more
openaire   +1 more source

PERFORMANCE OF CONGLOMERATE FIRMS: COMMENT

The Journal of Finance, 1973
A RECENT ARTICLE in this Journal by Weston and Mansinghka concludes by observing ". . . that an important economic function of conglomerate firms has been the raising of the profitability of firms with depressed earnings to the average for the industry generally."' Likewise, W-M conclude that their findings are ". . . contrary to the general impression
openaire   +1 more source