Results 61 to 70 of about 1,899 (235)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
An Entailment of Dead Days Comic
, 2017 The aim of this study was to analyze linguistic phenomenon of entailment in the Dead Days comic, the conversation all characters in Dead Days comic. This study had two objectives. They were to identify the types of entailment and the dominant types of
core
Semantic Methods for Textual Entailment
, 2011 The problem of recognizing textual entailment (RTE) has been recently addressed using syntactic and lexical models with some success. Here, a new approach is taken to apply world knowledge in much the same way as humans, but captured in large semantic ...
Max H. Garzon +3 more
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
A class of 4-valued implicative expansions of first-degree entailment logic (FDE) with the variable-sharing property [PDF]
[EN] Anderson and Belnap consider the variable-sharing property (VSP) a necessary property a relevance logic has to fulfill. A logic L has the VSP if in all L-theorems of implication form antecedent and consequent share at least a propositional variable.
Robles Vázquez, Gemma +1 more
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
, 1991 Approximation techniques are widely used in many areas of Computer Science for dealing with polynomially intractable problems. The major difficulty about introducing approximation in reasoning problems is in that it is very hard to find a measure of the ...
Marco Cadoli +3 more
core +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source