Results 51 to 60 of about 174,416 (267)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Large Language Model and Fuzzy Metric Integration in Assignment Grading for Introduction to Programming Type of Courses

Mathematics
The integration of large language models (LLMs) and fuzzy metrics offers new possibilities for improving automated grading in programming education. While LLMs enable efficient generation and semantic evaluation of programming assignments, traditional ...
Rade Radišić, Srđan Popov, Nebojša Ralević   +2 more
doaj   +1 more source

ARG: Automatic ROP Chains Generation

IEEE Access, 2019
Return Oriented Programming (ROP) chains attack has been widely used to bypass Data Execution Prevention (DEP) and Address Space Layout Randomization (ASLR) protection.
Yuan Wei, Senlin Luo, Jianwei Zhuge, Jing Gao, Ennan Zheng, Bo Li, Limin Pan   +6 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Representación de aspectos candidato en esquemas preconceptuales Representing candidate aspects by means of pre-conceptual schemes

Revista Ingenierías Universidad de Medellín, 2010
Aspects have been gradually consolidating as a new software development paradigm. Although aspects are already common in programming, as aspect-oriented languages have shown, aspect evolution is currently going to the first phases of software development
Carlos Mario Zapata Jaramillo, Guillermo González Calderón, Gabriel Eduardo Orozco   +2 more
doaj  

Large Language Model–Based Critical Care Big Data Deployment and Extraction: Descriptive Analysis

JMIR Medical Informatics
BackgroundPublicly accessible critical care–related databases contain enormous clinical data, but their utilization often requires advanced programming skills.
Zhongbao Yang, Shan-Shan Xu, Xiaozhu Liu, Ningyuan Xu, Yuqing Chen, Shuya Wang, Ming-Yue Miao, Mengxue Hou, Shuai Liu, Yi-Min Zhou, Jian-Xin Zhou, Linlin Zhang   +11 more
doaj   +1 more source

CauseMap: fast inference of causality from complex time series [PDF]

PeerJ, 2015
Background. Establishing health-related causal relationships is a central pursuit in biomedical research. Yet, the interdependent non-linearity of biological systems renders causal dynamics laborious and at times impractical to disentangle.
M. Cyrus Maher, Ryan D. Hernandez
doaj   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Supporting Java programming in the Svace static analyzer

Труды Института системного программирования РАН, 2018
The paper is devoted to the works performed within the Svace static analysis tool to support Java language. First, the approach to intercept compilation process for transparently building the analyzer internal representation should be extended to cover ...
A. P. Merkulov, S. A. Polyakov, A. A. Belevantsev   +2 more
doaj   +1 more source