Results 31 to 40 of about 231,799 (218)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Return-to-Play Timeline and Recovery Predictors After COVID-19 Infection in Elite Football Players

Sports
The pandemic period significantly impacted professional football, leading to mandatory SARS-CoV-2 testing and quarantine. Our study aimed to examine the factors influencing time of recovery after a positive test, including return-to-training (RTT) and ...
Agnes Sziva, Zsuzsanna Kives, Zsolt Szelid   +2 more
doaj   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Endoscopic versus open surgery for insertional achilles tendinopathy: A systematic review and meta‐analysis of comparative outcomes

Journal of Experimental Orthopaedics
Purpose Insertional Achilles tendinopathy (IAT) causes chronic hindfoot pain and functional impairment. Although conservative treatment remains the first‐line management approach, surgery is often necessary when nonoperative measures fail.
Po‐Yuan Chen, I‐Shiang Tzeng, Kai‐Chiang Yang, Chen‐Chie Wang   +3 more
doaj   +1 more source

Mapping the acute trajectory of sport-related concussion outcomes across symptoms, cognition, and blood biomarkers

Sports Medicine and Health Science
Sport-related concussion (SRC) and its potential neurological sequela represent an emerging global health concern, requiring improved recovery management and strategies for return-to-play (RTP) to enhance brain health in athletes.
SoYoung Ahn, Michael Prock, Ji-won Seo, Sanghyuk Han, David Michael O'Sullivan, Wook Song   +5 more
doaj   +1 more source

Water drinking during aerobic exercise improves the recovery of non-linear heart rate dynamics in coronary artery disease: crossover clinical trial

Frontiers in Neuroscience, 2023
IntroductionThe post-exercise recovery is a period of vulnerability of the cardiovascular system in which autonomic nervous system plays a key role in cardiovascular deceleration.
Maria Júlia Lopez Laurino, Anne Kastelianne França da Silva, Lorena Altafin Santos, Luiz Carlos Marques Vanderlei   +3 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Recovery and Return to Activity 1 Year After Ankle Fracture Managed With Open Reduction and Internal Fixation: A Prospective Longitudinal Cohort Study

Foot & Ankle Orthopaedics, 2022
Background: Ankle fractures are common and frequently managed with open reduction and internal fixation (ORIF). Although these fractures can occur at any age, they are most common in younger individuals with high-energy trauma or older adults with lower ...
Ailar Ramadi PT, PhD, Lauren A. Beaupre PT, PhD, Luke Heinrichs MD, M. Elizabeth Pedersen MD, MSc   +3 more
doaj   +1 more source

Science policy frameworks for a post-pandemic green economic recovery

Energy Strategy Reviews, 2023
As current production and consumption patterns exceed planetary boundaries, many leaders have stressed the need to adopt green economic stimulus policies in the aftermath of the COVID-19 pandemic.
Theodoros Zachariadis, Elias Giannakis, Constantinos Taliotis, Marios Karmellos, Nestor Fylaktos, Mark Howells, Will Blyth, Stéphane Hallegatte   +7 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source