Results 1 to 10 of about 15,239,872 (341)
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source
Ultrasound diagnostics of traumatic pancreatitis at combined trauma
Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2014 Aim of investigation. To estimate state of the pancreas in patients with combined trauma, to detect signs of traumatic pancreatitis.Material and methods. Analysis of ultrasound data in 680 patients with combined trauma was carried out. In 57 patients (42
O. A. Alekseyechkina +3 more
doaj
Cochrane First Aid: The Next Step Towards Evidence-based First Aid
International Journal of First Aid Education, 2021 An introduction to Cochrane First Aid, a global independent network that envisions a world of improved health, where decisions about health and health care are informed by high-quality, relevant and up-to-date synthesized research evidence, it provides ...
doaj +2 more sources
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
International Journal of Mental Health Systems, 2021 Background Suicide is a significant concern in Australia and globally. There is a strong argument for training community gatekeepers in how to recognise and support suicidal people in their social network.
Kathy S. Bond +8 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source