Results 171 to 180 of about 1,101,220 (313)
Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh +8 morewiley +1 more sourceLiquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen +2 morewiley +1 more sourceIntein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar +9 morewiley +1 more source2021 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Neonatal Life Support; Education, Implementation, and Teams; First Aid Task Forces; and the COVID-19 Working Group
, 2021 Myra H. Wyckoff, Eunice M. Singletary, Jasmeet Soar, Theresa M. Olasveengen, Robert Greif, Helen G. Liley, David Zideman, Farhan Bhanji, Lars W. Andersen, Suzanne R. Avis, Khalid Aziz, Jason C. Bendall, David C. Berry, Vere Borra, Bernd W. Böttiger, Richard Bradley, Janet E. Bray, Jan Breckwoldt, Jestin N. Carlson, Pascal Cassan, Maaret Castrén, Wei-Tien Chang, Nathan P. Charlton, Adam Cheng, Sung Phil Chung, Julie Considine, Daniela T. Costa-Nobre, Keith Couper, Katie N. Dainty, Peter G. Davis, Maria Fernanda de Almeida, Allan R. de Caen, Edison F. de Paiva, Charles D. Deakin, Therese Djärv, Matthew J. Douma, Ian R. Drennan, Jonathan P. Duff, Kathryn J. Eastwood, Walid El-Naggar, Jonathan L. Epstein, Raffo Escalante, Jorge G. Fabres, Joe Fawke, Judith C. Finn, Elizabeth E. Foglia, Fredrik Folke, Karoline Freeman, Elaine Gilfoyle, Craig A. Goolsby, Amy Grove, Ruth Guinsburg, Tetsuo Hatanaka, Mary Fran Hazinski, George S. Heriot, Karen G. Hirsch, Mathias J. Holmberg, Shigeharu Hosono, Ming-Ju Hsieh, Kevin K.C. Hung, Cindy H. Hsu, Takanari Ikeyama, Tetsuya Isayama, Vishal S. Kapadia, Mandira Daripa Kawakami, Han-Suk Kim, David A. Kloeck, Peter J. Kudenchuk, Anthony T. Lagina, Kasper G. Lauridsen, Eric J. Lavonas, Andrew S. Lockey, Carolina Malta Hansen, David Markenson, Tasuku Matsuyama, Christopher J.D. McKinlay, Amin Mehrabian, Raina M. Merchant, Daniel Meyran, Peter T. Morley, Laurie J. Morrison, Kevin J. Nation, Michael Nemeth, Robert W. Neumar, Tonia Nicholson, Susan Niermeyer, Nikolaos Nikolaou, Chika Nishiyama, Brian J. O’Neil, Aaron M. Orkin, Osokogu Osemeke, Michael J. Parr, Catherine Patocka, Jeffrey L. Pellegrino, Gavin D. Perkins, Jeffrey M. Perlman, Yacov Rabi, Joshua C. Reynolds, Giuseppe Ristagno, Charles C. Roehr +99 moreopenalex +2 more sourcesImproving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann +15 morewiley +1 more source