Results 201 to 210 of about 4,419,277 (309)

Effect of psychological first aid training for fellows on resident burnout and distress in the intensive care unit. [PDF]

PLoS One
Belt H, North CS, Adams TN.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Strengthening trauma care in South Africa: Tier 1 integration of emergency first aid responder (EFAR) programmes with emergency medical services. [PDF]

Afr J Emerg Med
Abdullah N, De Vos S, Slingers M, Hendrikse C, Geduld H.   +4 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Relevance of anatomical knowledge in first aid: A three-year study of medical students' perspective. [PDF]

Medicine (Baltimore)
Al Sharei A, Yousuf MS, Almaraziq BI, Dawoud R, Iqneibi S, Tayeh L, Alzboon D, Al-Dwairy S.   +7 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Optimizing Inpatient Stroke Care: Multidisciplinary Approaches in Kazakhstan

Advances in Public Health
Gulzhan Adenova, Galina Kausova, Alexander Brukhanov, Almaz Juvashev, Bakyt Utaganov, Lyazzat Ayaganova, Zhanna Dyusembayeva, Aiken Orazymbetova, Maigul Tolepbergenova, Syrsulu Myrzagulova, Konstantin Bulygin, Aigul Tazhiyeva   +11 more
doaj   +1 more source

Developing, piloting, and evaluating a psychological first aid training for medical students in South Africa. [PDF]

BMC Med Educ
Bantjes J, Geldenhuys M, Van Zyl M, Page DT, Weis J, Louw KA, Shadwell R, Hunt X.   +7 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Development and Psychometric Evaluation of the Psychological First Aid Competence (PFAC) Scale for Emergency Responders: A Cross-Sectional, Sequential-Exploratory Mixed-Methods Study. [PDF]

Health Sci Rep
Rajai N, Marzaleh MA, Ostadtaghizadeh A, Azizi M.   +3 more
europepmc   +1 more source