Results 161 to 170 of about 86,443 (302)

Associations Between Rumination and the Incidence of First-Episode Major Depressive Disorder in a Sample of Chinese University Students: From a 1-Year Longitudinal Study. [PDF]

Depress Anxiety
Guo N, Zheng Y, Xu R, Niu X, Qin Y, Li H, Wang J, Liu Y.   +7 more
europepmc   +1 more source

Dual role of spreading depolarization in an epileptic focus

Epilepsia, EarlyView.
Abstract Objective Spreading depolarizations (SDs) are often associated with epileptic discharges. Although SDs are traditionally thought to contribute to postictal depression and termination of epileptic discharges, seizures may also occur during SDs or may even follow SDs, suggesting that interactions between SD and seizures are more complex.
Daria Vinokurova, Karina Tukhvatullina, Roustem Khazipov, Azat Nasretdinov   +3 more
wiley   +1 more source

Diminished caudate and superior temporal gyrus responses to effort-based decision making in patients with first-episode major depressive disorder

, 2016
Background: Anhedonia, the loss of interest or pleasure in reward processing, is a hallmark feature of major depressive disorder (MDD), but its underlying neurobiological mechanism is largely unknown.
Yang, Xin-hua, Chan, Raymond C. K., Xie, Guang-rong, Cheung, Eric F. C., Liu, Xiao-qun, Huang, Jia, Wang, Ye-fei, Lan, Yong, Zhu, Cui-ying   +8 more
core  

An n‐of‐1 gene‐directed drug repurposing trial for an ultrarare genetic condition

Epilepsia, EarlyView.
Abstract Objective Gain‐of‐function (GoF) variants in the KCNC1 potassium channel subunit gene (Kv3.1) cause motor/cognitive delays and hypotonia and have been associated with seizures. Fluoxetine has inhibitory effects on Kv3.1. However, open‐label nonrandomized administration is insufficient to guide clinical decision‐making in ultrarare conditions ...
Vedika Jha, Christina Tsetsos, Mark Bedford, Gregory Costain, Sunita Vohra, Juan Pablo Diaz Martinez, Elise Heon, Jacob Vorstman, Carolina Gorodetsky, Ajoy Vincent, Jesiqua Rapley, Lori Anderson, Evdokia Anagnostou, Danielle A. Baribeau   +13 more
wiley   +1 more source

Effectiveness and Tolerability of Vortioxetine in Major Depressive Disorder: A Real-World Study in Switzerland. [PDF]

Clin Drug Investig
Kammerer M, Hasler G, Hochstrasser B, Baumann A, Sousek A.   +4 more
europepmc   +1 more source

Increased interval between seizure clusters across time in pediatric patients treated with the immediate‐use seizure medication diazepam nasal spray

Epilepsia, EarlyView.
Abstract Objective Seizure clusters, intermittent increases in seizure activity that differ from a patient's usual seizure pattern, may occur despite treatment with a daily anti‐seizure medication. Benzodiazepine‐containing immediate‐use seizure medications (ISMs; also called rescue therapies) are the cornerstone of treatment for seizure clusters ...
James W. Wheless, Eric Segal, Jurriaan M. Peters, Steven M. Wolf, Genei Bougher, Charles Davis, Leock Y. Ngo, Enrique Carrazana, Adrian L. Rabinowicz   +8 more
wiley   +1 more source

Cerebellar gray matter volume difference in first-episode bipolar and unipolar depression. [PDF]

BMC Psychiatry
Han Y, Sheng L, Wang S, Wen X, Lu W, Li P, Zhou Z, Guo Z, Gao Y.   +8 more
europepmc   +1 more source

Add‐on treatment with vinpocetine reduces seizure frequency and improves comorbidities in patients with loss‐of‐function γ‐aminobutyric acid type A receptor variants

Epilepsia, EarlyView.
Abstract Objective The semisynthetic compound vinpocetine has gained attention as a potential precision medicine for developmental and epileptic encephalopathies caused by loss‐of‐function (LoF) variants in γ‐aminobutyric acid type A (GABAA) receptor genes. As a positive allosteric modulator of GABAA receptors, case reports suggest that vinpocetine can
Cathrine E. Gjerulfsen, Vivian W. Y. Liao, Tomasz S. Mieszczanek, Anne V. Jakobsen, Elena Gardella, Kern Olofsson, Marina Nikanorova, Allan Bayat, Sebastian Ortiz, Sarah Weckhuysen, Cecilie Johannessen Landmark, Orrin Devinsky, Mary Chebib, Philip K. Ahring, Guido Rubboli, Rikke S. Møller   +15 more
wiley   +1 more source

Symptom network analysis of depressive and somatic symptoms and suicide risk indicators in treatment-naïve adolescents with first-episode depression. [PDF]

BMC Psychiatry
Liu G, An X, Wen X, Luo H, Wang X, Ren H, Zhong X, Gao Y, Yu S, Zhang J, Jafri GZ, Qiu H.   +11 more
europepmc   +1 more source

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

Epilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source