Results 81 to 90 of about 86,443 (302)

Prevalence and related factors of first-time suicide attempts in the past 14 days in Chinese adult patients with first-episode drug-naïve major depressive disorder

Frontiers in Psychiatry
BackgroundThis study aimed to identify socio-demographic, physiologic, and psychologic related factors of the first-time suicide attempt (FSA) in the past 14 days in Chinese adult patients with first-episode drug-naïve (FEDN) major depressive disorder ...
Xiaoyin Cong, Tian Zhang, Rongrong Bian, Yong Li, Junjun Liu, Xiangyang Zhang   +5 more
doaj   +1 more source

Resilience in the First Episode of Major Depressive Disorder

Open Journal of Medical Psychology, 2017
Aim: Resilience refers to the human ability to adapt to tragedy, trauma, adversity, and significant stressors. Recently, resilience has been defined as a potentially modifiable factor that can be improved through intervention. Here, we examined resilience during a 3-month period as patients experienced their first episode of major depressive disorder ...
Toshihiko Maekawa, Shingo Souda, Katsura Oyakawa, Mutsuhide Tanaka, Takao Yamasaki   +4 more
openaire   +2 more sources

De Novo 2.2 Mb 19q13.42–q13.43 Microdeletion Encompassing U2AF2: Support for a Haploinsufficiency Model

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT U2 small nuclear RNA auxiliary factor 2 (U2AF2) is an essential pre‐mRNA splicing factor involved in the early stages of pre‐mRNA splicing. To date, multiple individuals have been reported with predominantly heterozygous missense variants presenting intellectual disability, speech and motor delays, seizures, hypotonia, and thin or hypoplastic ...
Amanda Toledo, Sarah Araji, Weimin Bi, Seema R. Lalani   +3 more
wiley   +1 more source

Distinct Neuropsychiatric Profiles Associated With 17p11.2 Deletions and RAI1 Variants in Smith–Magenis Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Smith–Magenis syndrome (SMS) results from either a recurrent 17p11.2 deletion or pathogenic variants in the retinoic acid induced 1 gene (RAI1). While neurodevelopmental impairment and behavioral dysregulation are well recognized, systematic genotype‐stratified analyses across psychiatric domains remain limited.
Albin Blanc, Christophe Nemos, Céline Bonnet, Mathilde Renaud, Sandra Chapuis, Pauline Boiroux, Marie‐Noëlle Babinet, Caroline Demily   +7 more
wiley   +1 more source

Increased prefrontal and parietal cortical thickness does not correlate with anhedonia in patients with untreated first-episode major depressive disorders

, 2015
Cerebral morphological abnormalities in major depressive disorder (MDD) may be modulated by antidepressant treatment and course of illness in chronic medicated patients.
Wang, Yi, Yang, Xin-hua, Chan, Raymond C. K., Xie, Guang-rong, Cheung, Eric F. C., Liu, Xiao-qun, Huang, Jia, Zhu, Cui-ying   +7 more
core  

Factors influencing suicidal ideation in Chinese adolescents with first-episode depressive disorder: a cross-sectional study

BMC Psychology
Background Given the high prevalence and severe consequences of suicidal ideation (SI) in adolescents, it is critical to identify multidimensional predictors of the illness.
Yang Zhang, Xingbo Suo, Jingjing Xu, Wu Li, Xinqi Wang, Wangwang Xu, Liangke Pan, Jingxue Wang, Jin Gao   +8 more
doaj   +1 more source

Psychiatric and Cognitive Features in Italian Women With the FMR1 Premutation: A Comprehensive Assessment Using SCID‐5 and Standardized Cognitive Measures

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Women with the FMR1 premutation (PM) are at increased risk for fragile X‐associated conditions (FXPAC), including cognitive and psychiatric features collectively termed fragile X‐associated neuropsychiatric disorders (FXAND). This study is the first to systematically investigate cognitive and psychiatric features in Italian female premutation ...
Federica Alice Maria Montanaro, Randi J. Hagerman, Giuseppina Spano, Flora Tassone, Giancarlo Logroscino, Andrea Bosco   +5 more
wiley   +1 more source

Altered fibrinolytic system in rat models of depression and patients with first-episode depression

Neurobiology of Stress, 2019
Tissue plasminogen activator (tPA) is a serine protease involved in cleavage of neurotrophic factors. In addition, tPA and neuroserpin can also directly bind to low density lipoprotein receptor-related protein 1 (LRP1), promoting neurogenesis and neurite outgrowth.
Wenxiu Han, Ruili Dang, Pengfei Xu, Gongying Li, Xueyuan Zhou, Lei Chen, Yujin Guo, Mengqi Yang, Dan Chen, Pei Jiang   +9 more
openaire   +3 more sources

Psychotic and affective symptoms of early-onset bipolar disorder: an observational study of patients in first manic episode

Brazilian Journal of Psychiatry
Objective: Presence of psychotic symptoms seems to be a commonplace in early-onset bipolar disorder (BD). However, few studies have examined their occurrence in adolescent-onset BD.
Lee Fu-I, Wagner de S. Gurgel, Sheila C. Caetano, Rodrigo Machado-Vieira, Yuan P. Wang   +4 more
doaj   +1 more source

Genetic Risk and High Burden of Depression and Suicide in the Maya‐Mestizo Population of Yucatán, México

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Major depression and suicide are critical public health concerns, particularly in underrepresented populations with unique genetic and sociocultural contexts. The Maya‐mestizo population presents the highest suicide rates in the country but remains understudied in psychiatric genetics. This study evaluated the association between three genetic
Marta Menjivar, Erandi Bravo, Margarita Rivera‐Balancan, Barbara Itzel Pena Espinoza   +3 more
wiley   +1 more source