Results 111 to 120 of about 16,191,636 (293)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Neuroradiological abnormalities in individuals with first-episode psychosis – a retrospective cohort study

BMC Psychiatry
Background While psychosis mostly results from psychiatric conditions, certain organic disorders may also cause psychotic symptoms. Therefore, some diagnostic guidelines recommend people with first-episode psychosis (FEP) receive magnetic resonance ...
Marie-Christine Khorsandian, Gianluca Bonfiglio, Karen J. Schulz, Franziska C. Graetz, Andreas Hofmann, Anne Henriette Hövel, Mario Müller, Claudio Corda, Philipp Homan, Erich Seifritz, Achim Burrer, Tobias R. Spiller   +11 more
doaj   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

First Argentine Consensus on the Management of Schizophrenia: Section Two. Clinical and Diagnostic Considerations

Vertex Revista Argentina de Psiquiatría
This document constitutes the second part of the First Argentine Consensus on the Management of Schizophrenia and provides an updated summary of the available evidence on the clinical and diagnostic aspects of the disorder in adults.
Alejo Corrales, Andrea Abadi, Asociación de Ayuda de Familiares de Personas con Esquizofrenia (AAFE), Gastón Bartoli, Carlos Benavente Pinto, Adrián Cabrera, Sebastián Camino, Ricardo Corral, Guillermo Delmonte, Gerardo García Bonetto, Cristian Javier Garay, Damián Gargoloff, Pedro Gargoloff, Aníbal Goldchuk, María Florencia Iveli, Gabriela Jufe, Fabián Lamaison, Eduardo Leiderman, Andrea López Mato, Eliana Marengo, Tomás Maresca, María Delia Michat, Carlos Morra, Cintia Prokopez, Julieta Ramírez, Federico Rebok, Eduardo Rubio Domínguez, Daniel Sotelo, Sergio Strejilevich, Esteban Toro Martínez, Gustavo Vázquez, Juan José Vilapriño, Manuel Vilapriño, Marcela Waisman Campos, Verónica Grasso, Marcelo Cetkovich-Bakmas   +35 more
doaj   +1 more source

Comparison of Residual Depressive Symptoms, Functioning, and Quality of Life Between Patients with Recurrent Depression and First Episode Depression After Acute Treatment in China

Neuropsychiatric Disease and Treatment, 2021
Si Zu,1 Dong Wang,1 Jiexin Fang,1 Le Xiao,2 Xuequan Zhu,2 Wenyuan Wu,3 Gang Wang,2,4 Yongdong Hu1 1Department of Psychiatry, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2The National Clinical Research ...
Zu S, Wang D, Fang J, Xiao L, Zhu X, Wu W, Wang G, Hu Y   +7 more
doaj  

The Formation of Low-Mass Double White Dwarfs through an Initial Phase of Stable Non-Conservative Mass Transfer

, 2010
Although many double white dwarfs (DWDs) have been observed, the evolutionary channel by which they are formed from low-mass/long-period red-giant-main-sequence (RG-MS) binaries remains uncertain. The canonical explanations involve some variant of double
Chaichenets, S., Ivanova, N., van der Sluys, M., Woods, T. E.   +3 more
core   +1 more source