Results 191 to 200 of about 347,512 (265)

Longitudinal Phenotypic Trajectories in GNAO1‐Related Disorders: Defining Disease Progression and Clinical Profiles

Annals of Neurology, EarlyView.
Objective Pathogenic variants in GNAO1 cause a spectrum of epilepsy, movement disorders, and developmental impairment. Clinical heterogeneity complicates prognosis and therapeutic development. We present the first longitudinal natural history study of GNAO1‐related disorders (GNAO1‐RD) to delineate phenotypic trajectories. Methods Sixty‐six individuals
Jana Domínguez‐Carral, Ana María Domínguez Cobo, Sol Balsells, Anna Aguilar‐Ros, Chu‐Ting Chang, William G. Ludlam, Kathryn Yang, Katerina Bernardi, Micaela Chinigioli, Ainara Salazar‐Villacorta, Veronica Di Pisa, Nuria Lamagrande‐Casanova, Elena González‐Alguacil, Beatriz De la Casa‐Fages, Akihisa Okumura, Josefina Rodríguez, Ayush Agarwal, Daniela Muñoz‐Chesta, Carolina Reynoso‐Osnayo, Amy Lin, Brahim Tabarki, Jobaida Parvin, Adolfo Alberto Gallo, Andreia Forno, Fabian Maass, Johnny Montiel Blanco, Salomé Nasif, Elizabeth Jennions, Jorge Luis Ramón‐Gómez, Helene Verhelst, Juan José Nieto Barceló, Dunja Čokolić Petrović, Luz Victoria García Ruiz, Christoph van Riesen, Paulo Rego Sousa, Maria del Pilar Massaro Sanchez, Husnea Ara Khan, Wejdan Hakami, Jennifer Friedman, Iván Espinoza‐Quinteros, Monica Troncoso, Divyani Garg, Micaela Pauni, Hirokazu Kurahashi, María Concepción Miranda‐Herrero, Anna Duat‐Rodriguez, Luca Soliani, Manju A. Kurian, Angeles Schteinschnaider, Siddharth Srivastava, Darius Ebrahimi‐Fakhari, Kirill A. Martemyanov, Juan Darío Ortigoza‐Escobar   +52 more
wiley   +1 more source

Peripheral blood immune markers associated with negative symptoms in first episode psychosis: a systematic review. [PDF]

Front Psychiatry
Ingabire G, Scarabelot LF, Del-Ben CM, Corsi-Zuelli F.   +3 more
europepmc   +1 more source

Cerebrospinal Fluid Amyloid‐β Biomarkers Predict Future Hemorrhage in Patients with Cerebral Amyloid Angiopathy

Annals of Neurology, EarlyView.
Objective Accurately predicting future hemorrhagic events in patients with cerebral amyloid angiopathy (CAA) remains a major clinical challenge. It is unknown whether cerebrospinal fluid (CSF) biomarkers of amyloid‐beta (Aβ) pathology are associated with increased hemorrhage risk in this population.
Philipp Arndt, Malte Pfister, Valentina Perosa, Hendrik Mattern, Melis Tas, Lara Holzheimer, Johanna Engel, Marc Dörner, Marwa Al‐Dubai, Cornelia Garz, Eya Khadhraoui, Sebastian J. Müller, Patrick Müller, Sven G. Meuth, Katja Neumann, Stefanie Schreiber   +15 more
wiley   +1 more source

Divergence of C4A and C4B in first-episode psychosis: Insights from CSF and plasma immune profiling. [PDF]

Transl Psychiatry
Arjmand S, Chaudhary M, Samudyata, Piehl F, Pelanis A, Engberg G, Cervenka S, Landén M, Erhardt S, Sellgren CM.   +9 more
europepmc   +1 more source

Proinflammatory Epstein–Barr Virus Antibody Functions Track with Disease Activity in Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Epstein–Barr virus (EBV) has been implicated in the pathogenesis of multiple sclerosis (MS). Elevated immunoglobulin G (IgG) titers against EBV nuclear antigen 1 (EBNA1) represent the most consistent serological marker of MS risk, with levels remaining persistently elevated following disease onset.
Malina Behrens, Paula Terroba‐Navajas, Eline A.J. Willemse, Sabine Schädelin, Manuel Comabella, Christian Münz, Gordan Lauc, Yannic Bartsch, Jens Kuhle, Jan D. Lünemann   +9 more
wiley   +1 more source

Association of NOS3 rs1799983 Polymorphism with Cognitive Function in Patients with First Episode Depression. [PDF]

Clin Psychopharmacol Neurosci
Yin Y, Tang L, Xia J, Chang J, Qian M, Chen F, Li S, Gu X.   +7 more
europepmc   +1 more source

Comparable Infection Risk of Ocrelizumab and Rituximab in Multiple Sclerosis in a Nationwide Swedish Cohort Study

Annals of Neurology, EarlyView.
In multiple sclerosis (MS), anti‐CD20 therapies have been associated with increased infection risk, but whether this risk differs between rituximab and ocrelizumab is not known. Using a nationwide cohort, we studied infection risk and relapse outcomes among 16,872 treatment episodes with rituximab, ocrelizumab, or other disease‐modifying therapies ...
Thomas Frisell, Sebastian Hedberg, Fredrik Piehl   +2 more
wiley   +1 more source

Duration of Untreated Psychosis, Treatment Response, and Resting State Functional Connectivity in Antipsychotic-Naïve First-Episode Psychosis Patients. [PDF]

Schizophr Bull Open
Patton HN, Maximo JO, Lahti AC.
europepmc   +1 more source

Development and Characterization of Ribes nigrum Extract‐Loaded PLGA/Chitosan Nanoparticles as a Vaginal Drug Delivery System for Vulvovaginal Candidiasis

Journal of Applied Polymer Science, EarlyView.
Ribes nigrum extract‐loaded PLGA/chitosan nanoparticles is developed as a vaginal drug delivery system for vulvovaginal candidiasis. The chitosan‐coated nanoparticles exhibit favorable physicochemical properties, strong mucoadhesion, sustained release for up to 2 weeks, excellent biocompatibility, and potent antifungal activity against Candida albicans,
Ayca Aslan Aras, Deniz Uygunoz, Emre Karaduman, Neslihan Merve Eren, Secil Gunay Avci, Mehmet Burcin Piskin, Emek Moroydor Derun   +6 more
wiley   +1 more source

Symptom network analysis of depressive and somatic symptoms and suicide risk indicators in treatment-naïve adolescents with first-episode depression. [PDF]

BMC Psychiatry
Liu G, An X, Wen X, Luo H, Wang X, Ren H, Zhong X, Gao Y, Yu S, Zhang J, Jafri GZ, Qiu H.   +11 more
europepmc   +1 more source