Results 71 to 80 of about 347,512 (265)

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Metabolic and Microvascular Risk Factors Associated With Brain Health in Type 1 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We examined relationships between metabolic factors, microvascular complications, and brain health in adults with type 1 diabetes. Fifty‐one adults were assessed for metabolic risk factors, microvascular complications, and cognitive function, with a subset completing brain MRI.
Jihyun Park, Emily J. Koubek, Richard Beare, Lynn Ang, Brian C. Callaghan, Rodica Pop‐Busui, Eva L. Feldman, Evan L. Reynolds   +7 more
wiley   +1 more source

First Argentine Consensus on the Management of Schizophrenia: Section Two. Clinical and Diagnostic Considerations

Vertex Revista Argentina de Psiquiatría
This document constitutes the second part of the First Argentine Consensus on the Management of Schizophrenia and provides an updated summary of the available evidence on the clinical and diagnostic aspects of the disorder in adults.
Alejo Corrales, Andrea Abadi, Asociación de Ayuda de Familiares de Personas con Esquizofrenia (AAFE), Gastón Bartoli, Carlos Benavente Pinto, Adrián Cabrera, Sebastián Camino, Ricardo Corral, Guillermo Delmonte, Gerardo García Bonetto, Cristian Javier Garay, Damián Gargoloff, Pedro Gargoloff, Aníbal Goldchuk, María Florencia Iveli, Gabriela Jufe, Fabián Lamaison, Eduardo Leiderman, Andrea López Mato, Eliana Marengo, Tomás Maresca, María Delia Michat, Carlos Morra, Cintia Prokopez, Julieta Ramírez, Federico Rebok, Eduardo Rubio Domínguez, Daniel Sotelo, Sergio Strejilevich, Esteban Toro Martínez, Gustavo Vázquez, Juan José Vilapriño, Manuel Vilapriño, Marcela Waisman Campos, Verónica Grasso, Marcelo Cetkovich-Bakmas   +35 more
doaj   +1 more source

A 17 Year Old With Developmental Delay Presenting With Increasing Confusion and Imbalance

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Methylmalonic acidemia is an autosomal recessive genetic disorder primarily caused by defects in methylmalonyl‐CoA mutase and cobalamin (vitamin B12) metabolism. These defects disrupt the tricarboxylic acid cycle and oxidative phosphorylation, leading to the abnormal accumulation of metabolic products such as methylmalonic acid, propionic acid,
Wei Zhao, Yingli Zhang, Hongliang Zheng
wiley   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Comparison of Residual Depressive Symptoms, Functioning, and Quality of Life Between Patients with Recurrent Depression and First Episode Depression After Acute Treatment in China

Neuropsychiatric Disease and Treatment, 2021
Si Zu,1 Dong Wang,1 Jiexin Fang,1 Le Xiao,2 Xuequan Zhu,2 Wenyuan Wu,3 Gang Wang,2,4 Yongdong Hu1 1Department of Psychiatry, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2The National Clinical Research ...
Zu S, Wang D, Fang J, Xiao L, Zhu X, Wu W, Wang G, Hu Y   +7 more
doaj  

First episode depression in women- a study of clinical characteristics through the female reproductive stages in a rural tertiary care center in Kerala

Kerala Journal of Psychiatry, 2019
Background: The lifetime prevalence of major depressive disorders is 10-25% for women and 5-12% for men. Women are more prone to develop depressive episode from the period of menarche to the perimenopausal period. Relatively little research has been done
Joice Geo, Jismi B Krishnan, Mareen Benjamin, Roy Abraham Kallivayalil   +3 more
doaj   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier, Ugo Sorrentino, Matias Wagner, Marta Zawadzka, Anna Lemska, Maria Mazurkiewicz‐Bełdzińska, Michael Zech   +6 more
wiley   +1 more source

Fronto-striato network function is reduced in major depressive disorder

Frontiers in Psychiatry
IntroductionMajor depressive disorder (MDD) is a major cause of poor quality of life and disability and is highly prevalent worldwide. Various pathological mechanisms are implicated in MDD, including the reward system.
Reoto Kijima, Keita Watanabe, Naomichi Okamoto, Atsuko Ikenouchi, Hirofumi Tesen, Shingo Kakeda, Reiji Yoshimura   +6 more
doaj   +1 more source