Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
On the functional redundancy of alcohol tolerance in rice societies. [PDF]
Wigger B.
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ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Fat intravasation, fat emboli and fat embolism syndrome in adult major trauma patients with intraosseous catheters: a systematic review. [PDF]
Ellington M, Hibberd O, Aylwin C.
europepmc +1 more source
The control of mushroom pathogen Lecanicillium fungicola with fungicides and Bacillus-based biocontrol treatments during crop trial studies. [PDF]
Clarke J +3 more
europepmc +1 more source
Saline flushing to prevent circuit clotting during CRRT without anticoagulant: a randomized controlled study. [PDF]
Wang F +12 more
europepmc +1 more source
Comparative Evaluation of Follicular Flushing Frequency and Scraping Time During Ovum Pick-Up in Mares: Effects on Oocyte Recovery Rate and Technical Considerations. [PDF]
Márquez-Moya A +4 more
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Applying gastric residual volume as one of the indicators for enteral feeding intolerance: A scoping review. [PDF]
Nguyen DT +7 more
europepmc +1 more source
Uterine epithelial estrogen receptor α temporally regulates preimplantation uterine immunity involving interleukin-1β signaling. [PDF]
Hancock JM +7 more
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