Results 201 to 210 of about 14,686,178 (292)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Stability of Rayleigh-Jeans Equilibria in the Kinetic FPU Equation. [PDF]

Arch Ration Mech Anal
Germain P, La J, Menegaki A.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Safety and feasibility of a novel oesophageal stimulation protocol in modulating aerodigestive mechanisms and outcomes in infants at-risk for gastrostomy: a pilot study. [PDF]

EClinicalMedicine
Jadcherla SR, Helmick R, Osborn EK, Alshaikh ES.   +3 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Kinetic Characterization of Barley Straw Carbonization Using the Distributed Activation Energy Model (DAEM). [PDF]

ACS Omega
Pallarés Ranz J, Cortés C, Gil A, Arauzo I.   +3 more
europepmc   +1 more source

Integrity-First Procurement

Integrity-First Procurement™ is a BGC standard developed by the Centre for Research, Standards & Human Integrity of Britannia Global Certification Services as a practical, evidence-based framework within the category “Enterprises”.
openaire   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Integral equations of the first kind of Sonine type

International Journal of Mathematics and Mathematical Sciences, 2003
Stefan G. Samko, Rogério P. Cardoso
doaj   +1 more source

A quadratic-scaling algorithm with guaranteed convergence for quantum coupled-channel calculations. [PDF]

Sci Adv
Jóźwiak HJ, Rahman MM, Tscherbul TV.
europepmc   +1 more source