Results 211 to 220 of about 26,268,555 (308)

Reduced-Dose Bendamustine as a First-Line Treatment of Follicular Lymphoma Is Associated With Poorer Prognosis. [PDF]

Cancer Med
Tanaka K, Takahata A, Noguchi Y, Okada K, Saito T, Mukae J, Osada Y, Suzuki K, Mizuchi D, Yamamoto K, Kumagai T, Oshikawa G, Mori T, Toyota S, Yamamoto M.   +14 more
europepmc   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Nivolumab Plus Lenvatinib and Intra-Arterial Locoregional Therapy as First-Line Treatment for Unresectable Hepatocellular Carcinoma: A Real-World Study. [PDF]

J Hepatocell Carcinoma
Gu S, Zhao Y, Yan H, Li M, Li G, Huang M, Xiong Z, Huang B.   +7 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Should weight loss be the first-line treatment for obstructive sleep apnoea? A pro-con debate. [PDF]

Eur Respir Rev
Patel SR, Ryan S.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Genomic Biomarkers for First-Line Treatment Selection in Metastatic Pancreatic Ductal Adenocarcinoma: A Narrative Review. [PDF]

Cancers (Basel)
Muddasani A, Abdelnoor A, Manne A.
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Patterns of first-line treatment selection in metastatic renal cell carcinoma: a real-world analysis from the Meet-URO 33-REGAL study. [PDF]

Ther Adv Med Oncol
Bimbatti D, Nasso C, Aspden D, Buti S, Antonj L, Signori A, Verzoni E, Lolli C, Di Napoli M, Fanelli M, De Lucia M, Masini C, Roviello G, Arduini D, Filippi R, Mennitto A, Sorarù M, Bozza G, Formisano L, Messina C, Bonomi L, Guida A, Fantinel E, Scagliarini S, Vitale MG, Chiellino S, Maiorano BA, Deppieri FM, Zucali PA, Cavo A, Caserta C, La Russa F, Conteduca V, Maines F, Zai S, Pierantoni F, Icardi M, Rescigno P, Di Costanzo F, Banna GL, Rebuzzi SE.   +40 more
europepmc   +1 more source