Results 201 to 210 of about 975,233 (311)

<i>'I can contribute so much more but you have to untie my hands' -</i> a qualitative study of COVID-19 pandemic impacts on community pharmacist practice: lessons and future directions. [PDF]

Prim Health Care Res Dev
Marshall EG, Renaud L, Mathews M, Bishop A, Morrison B, Kennie-Kaulbach N, Trenaman S, Munene A, Bowles S, Bai I, Isenor JE.   +10 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Kinetics of RAFT Copolymerization of Vinyl Ether and Maleic Anhydride Monomers. [PDF]

Polymer (Guildf)
Acharya RT, Shah MZ, Woodruff A, Konkolewicz D.   +3 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Organic Psychosis Secondary to Untreated Graves' Disease: A Case Report. [PDF]

Cureus
Ahmad KA, Che Man M.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

First clinical experience in man with the IMRICOR-MR-EP system:Electrophysiology study guided by real-time MRI

Journal of Cardiovascular Magnetic Resonance, 2012
Gutberlet Matthias, Grothoff Matthias, Eitel Charlotte, Lücke Christian, Sommer Philip, Piorkowski Christopher, Hindricks Gerhard   +6 more
doaj   +1 more source

A 40-Year-Old Man With 2-Year Chronic Epigastric Pain From a Retained 18-cm Toothbrush: Endoscopic Management and Clinical Decision-Making. [PDF]

Am J Case Rep
Hu J, Hu Y, Sun D, Ding S, Huang J.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source