Results 111 to 120 of about 15,441,399 (300)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Statistical Problems and Solutions in Onomastic Research: Exemplified by a Comparison of Given Name Distributions in Germany throughout the 20th Century [PDF]

open access: yes
The German Socio Economic Panel Study (SOEP) offers the rare opportunity to look at patterns of given names amongst a representative sample of more than 50,000 people born since 1900.
Gert G. Wagner, Denis Huschka
core  

Editorial: Jordan’s Principle PSA in American Sign Language

open access: yes, 2019
Jordan’s Principle is a legal rule named in memory of a very special little boy named Jordan RiverAnderson. Jordan’s Principle makes sure that all First Nations children get the services they need whenthey need them.
First Nations Child & Family Caring Society of Canada   +1 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

The anthroponymy of Dragoslavec Breg

open access: yesRasprave Instituta za Hrvatski Jezik i Jezikoslovlje, 2012
This study begins with introductory remarks on the settlement of Dragoslavec Breg in Gornje Međimurje. Particular reference is made to the history of its name, unofficial eponyms and population dynamics.
Anita Škvorc Branda
doaj  

Observational education in Denmark : an integrated approach [PDF]

open access: yes, 1977
This study focused on the form of special education in Denmark known as observational education (OE). Characteristics of the OE programs, its teachers and its pupils, were sought.
Heaton, Susan
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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