Results 81 to 90 of about 17,547,976 (293)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Paradigme dénominatif : le vocable initial prénominal et ses syntagmes

Multilinguales
Naming is a universal phenomenon ; societies distinguish themselves by having a complex system of standards that govern them. Our contribution attempts to address questions of the first name and denominational to which Algerian authors resort in order to
Yasmina Baghbagha
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Décryptage anthroponymique et ancrage culturel des prénoms des nouveau-nés dans la ville d’El Eulma

Multilinguales
The present contribution explores the reasons underlying the choice of names for newborns in the year 2018 in the city of El-Eulma, Algeria. Our investigation focuses on the various motivations behind the naming choices, adopting an onomastic perspective.
Nadji Khattab
doaj   +1 more source

A High Level of Circulating Valine Is a Biomarker for Type 2 Diabetes and Associated with the Hypoglycemic Effect of Sitagliptin

Mediators of Inflammation, 2019
Background. High levels of branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) were associated with an increased risk of hyperglycemia and the onset of diabetes.
Xiaoyu Liao, Bingyao Liu, Hua Qu, LinLin Zhang, Yongling Lu, Yong Xu, Zhaohui Lyu, Hongting Zheng   +7 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Migráns gyermekek névhasználata. Egyénnév-választás nyelvi-kulturális kontaktushelyzetben. [Naming children from immigrant families. Choice of given names in a situation of language and cultural contact]

Névtani Értesítő, 2013
Based on research done in 2012, this paper presents how immigrant children educated in present- day Hungarian public schools are named, paying special attention to name assimilation and acculturation.
Kecskés, Judit
doaj  

Diagnóstico como nome próprio Diagnostic as first name

Psicologia & Sociedade, 2010
Este artigo apresenta reflexões dentro do campo da saúde mental, considerada aqui enquanto produção histórica correlata ao surgimento da psiquiatria e do seu objeto, a doença mental.
Daiana Paula Milani Baroni, Rômulo Fabiano Silva Vargas, Sandra Noemi Caponi   +2 more
doaj   +1 more source