Results 221 to 230 of about 2,923,590 (337)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Spreadsheet containing underlying data. Column names are defined on the first sheet.

Yuya Ueda (22766242), Yoshinori Aoki (572079), Naoto Matsubara (18512271), Tetsuro Senda (22766245), Tomomi Tanaka (486405), Fumiya Tanaka (15838216), Masachika Masujima (1832479), Yuichi Tsuda (8968955), Hidetada Kiyofuji (18512277)   +8 more
openalex   +1 more source

A Sociolinguistic Analysis of the English First Name Culture in Hong Kong

, 2008
Seo-young Chae
openalex   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Linking patient records at scale with a hybrid approach combining contrastive learning and deterministic rules. [PDF]

Biol Methods Protoc
Cao C, Pillai J, Daraei S, Ghadermarzi S.   +3 more
europepmc   +1 more source

APA names Guillermo Corea first chief business innovation and growth officer [PDF]

openalex   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

MedicalPhoto: Open-Source Clinical Photo Management Software for Digital Transformation. [PDF]

Ann Dermatol
Kim MS, Chang SE, Kim GH, Navarrete-Dechent C, Kim S, Kim SH, Han SS.   +6 more
europepmc   +1 more source

U of Washington Names Dr. Omnell as Dental Dean / Oral Roberts Dental School is Dedicated / Dentist Heads School Boards Group / Dr. Goggins to Aid Director at Nidr / St. Louis Society Honors Two Dentists / Caffrey Named Director of TDA / 100 Attend First Murray Gavel Lecture / California Dentist Chairs Observance of Community Day / Thornton to Retire as Head of Dentsply / Prof. Richards Retires as Dental Educator at U of Michigan

, 1981

openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source