Results 91 to 100 of about 16,264,893 (304)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Integrating Atomistic Insights With Circuit Simulations via Transformer-Driven Symbolic Regression
IEEE Journal on Exploratory Solid-State Computational Devices and CircuitsThis article introduces a framework that establishes a cohesive link between the first principles-based simulations and circuit-level analyses using a machine learning-based compact modeling platform.
Md Rahatul Islam Udoy +4 more
doaj +1 more source
Carbon Monoxide Conversion: Insights from First-Principles Calculation
, 2011 Carbon Monoxide Conversion: Insights from First-Principles ...
李微雪
core
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Effect of As and Ga doping on the electronic structure and photoelectric properties of cubic Ca2Ge
Materials Research Express, 2020 The electronic structure and optical properties of intrinsic and doped Ca _2 Ge have been calculated by using the first-principles calculation method based on density functional theory. The doping content of As were 2.08% and 1.04%, respectively, and the
Lin Lyu +4 more
doaj +1 more source
Guiding Principles Subgroup Policy: Residents' personal property, personal finances, and possessions
, 2023 These Guiding Principles are intended to support services when revising their local policies and procedures developed to meet the Schedule V requirements of the Health Act 2007 (Care and Support of Residents in Designated Centres for persons with ...
Guiding Principles Subgroup. Disability Services. Office of the National Quality Improvement Office
core
First-principles core energies of isolated basal and prism screw dislocations in magnesium
, 2022 We use first-principles energy density method (EDM) to calculate atomic energies for isolated 〈a〉-type basal and prism screw dislocation cores in Mg and compute line energies and core energy differences. The atomic energy distribution in the dislocations
Yang Dan (10920) +1 more
core +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
First-principles calculations of the structural, dynamical, and electronic properties of liquid MgO
, 2006 First-principles calculations of the structural, dynamical, and electronic properties of liquid ...
D Bhattarai (14446794) +2 more
core
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source