Results 121 to 130 of about 1,274,639 (308)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The first principles of photography : an elementary treatise on the scientific principles upon which practical photography depends / [PDF]
Includes index.Based on the author's lectures delivered since 1882 at the Dublin Mechanics' Institute and at the City of Dublin Technical Schools.Mode of access ...
Leaper, Clement J., author.
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Carbon Monoxide Conversion: Insights from First-Principles Calculation [PDF]
, 2011 Carbon Monoxide Conversion: Insights from First-Principles ...
李微雪
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Oxygen Driving Hydrogen Into the Inner Core: Implications for the Earth's Core Composition
Geophysical Research LettersEarth's core should contain light elements to account for the density deficit relative to pure iron as inferred from seismic observations. Of particular interest is hydrogen, as planetary accretion models predict the delivery of water possibly ...
Zhiming Zhang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
First-principles simulations of liquid silica: Structural and dynamical behavior at high pressure [PDF]
, 2007 First-principles simulations of liquid silica: Structural and dynamical behavior at high ...
D Bhattarai (14446794) +2 more
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Fushe yanjiu yu fushe gongyi xuebaoTa-doped lithium-lanthanum-zirconium-oxygen (Li6.5La3Zr1.5Ta0.5O12, LLZTO) solid electrolytes with a high ionic conductivity at room temperature were prepared by the solid-phase reaction method, and the effects of irradiated electron beams on their ...
WANG Daoxi +6 more
doaj +1 more source
First-Principles Assessment: Physicalism and Idealism at First Principles
Part of the Return to Consciousness research program (30 essays).
openaire +6 more sources