Results 101 to 110 of about 1,253,951 (268)
Scientific ReportsObjective: This study aims to investigate the mechanistic role of MYLK2 (myosin light chain kinase 2) in breast cancer and assess its potential as a prognostic biomarker for clinical applications. Methods: We performed a comprehensive analysis using gene
Zhitang Wang, Yazhen Cai, Debo Chen
doaj +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
A new species of the genus Conosiphon Becker, 1923 and the first records of this genus for Europe (Diptera, Asilidae). [PDF]
Zookeys, 2023 van den Broek R +2 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
Assemblage Theory: Recording the Archaeological Record: First Response
Epoiesen: A Journal for Creative Engagement in History and Archaeology, 2022 openaire +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
New records of amphipod crustaceans along the Israeli Mediterranean coast, including a rare Mediterranean endemic species, Maera schieckei Karaman & Ruffo, 1971 [PDF]
Biodiversity Data Journal, 2020 Sabrina Lo Brutto, Davide Iaciofano
doaj +3 more sources
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source