Results 51 to 60 of about 1,253,951 (268)

New distribution records for Sciomyzidae (Diptera) from the Pantanal, Brazil [PDF]

Check List, 2019
We document the geographical distribution of 6 species of Sciomyzidae from the Pantanal biome of Brazil. The species were collected in aquatic or semi-aquatic habitats from Mato Grosso and Mato Grosso do Sul.
Marcoandre Savaris, Frederico Dutra Kirst, Silvana Lampert, Luciane Marinoni   +3 more
doaj   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Integrated multi-omics analysis reveals TMEM147 as an immunosuppressive prognostic biomarker in LUAD

Biochemistry and Biophysics Reports
TMEM147, an endoplasmic reticulum (ER) membrane protein, is implicated in lung adenocarcinoma (LUAD) progression, although its precise role remains unclear.
Lei Ding, Yi Ding
doaj   +1 more source

First macrofossil record of Begonia (Begoniaceae) [PDF]

American Journal of Botany, 2011
Begonia is the sixth-largest genus of flowering plants, with about 1400-1500 species in 66 sections. Several species are popular with horticulturalists, mainly for their colorful flowers and leaves. However, the evolutionary history of the genus is debated, and until now there has been no macrofossil record.
Debra Z, Stults, Brian J, Axsmith
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Check list of the Hungarian Salticidae with biogeographical notes

Arachnologische Mitteilungen, 2003
An updated check list of the Hungarian jumping spider fauna is presented. 70 species are recorded from Hungary so far. Four species are new to the Hungarian fauna: Hasarius adansoni, Neon valentulus, Sitticus caricis, Synageles subcingulatus.
Szüts, Tamás, Szinetár, Csaba, Samu, Ferenc, Szita, Éva   +3 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Records of the Palni Hills Rudraksha Tree Elaeocarpus blascoi (Oxalidales Elaeocarpaceae) in Palni Hills, Tamil Nadu, India

Journal of Threatened Taxa, 2017
Elaeocarpus blascoi is an endemic tree species reported only from the Palni Hills in the Western Ghats of Tamil Nadu.  It was described from one tree in 1972, and was thought to be extinct till 1999.
Robert Stewart, Tanya Balcar
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source