Results 61 to 70 of about 1,253,951 (268)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Nachträge zum 'Katalog der schweizerischen Spinnen'. 3. Neunachweise von 1999 bis 2002 und Nachweise synanthroper Spinnen

Arachnologische Mitteilungen, 2003
In this third supplement to the Catalogue of Swiss spiders of Maurer & Hänggi (1990) 9 species are recorded for the first time for Switzerland. 4 additional species already published elsewhere are added to the list of Swiss spiders.
Hänggi, Ambros
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Spinnenaufsammlungen aus Ostösterreich mit vier Erstnachweisen für Österreich

Arachnologische Mitteilungen, 1995
95 species of spiders are reported, which were collected by hand and sweep-net during an excursion to Lower Austria and Burgenland in June 1993. New for Austria are: Larinia bonneti SPASSKY, 1939, Philodromus buddenbrocki BRAUN, 1965, Philodromus ...
Jäger, Peter
doaj   +1 more source

FIRST RECORD OF AEDES ALBOPICTUS IN GABON

Journal of the American Mosquito Control Association, 2007
Aedes albopictus were collected in the French military camp of Libreville, Estuaire Province, Gabon, from January to March 2007 by human landing catches during an entomological evaluation of malaria transmission. Inspection of potential larval habitats within and outside the camp showed that Ae.
T, Coffinet, J R, Mourou, B, Pradines, J C, Toto, F, Jarjaval, R, Amalvict, M, Kombila, P, Carnevale, F, Pages   +8 more
openaire   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

New records of protostrongylid lungworms from wild ruminants in Bulgaria

Veterinární Medicína, 2006
A necropsy of lungs from mouflons, chamois, red deerand fallow deer from Bulgariawas performed aiming at determining the species composition of protostrongylids. For the first time in the country Muellerius capillaris, Cystocaulus ocreatus, Neostrongylus
M.S. Panayotova-Pencheva
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

First records and rare species of Collembola in the Roumanian Fauna – The Piatra Craiului Massif (The Carpathians)

Travaux de l'Institut de Speologie Emile Racovitza, 2010
The author presents new data about the collembolan species collected from the Piatra Craiului Massif. Sixty-five species were identified from the material sampled from soil and mesovoid shallow substratum (M.S.S.) Three species (Arrhopalites ornatus ...
IONUŢ POPA
doaj