Results 71 to 80 of about 13,480,937 (242)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Note from Ruth First to Alpheus Manghezi [PDF]

A note left for Alpheus by Ruth First, arranging their first meeting in Maputo in ...
First, Ruth
core   +3 more sources

Implementation of the Enhanced Stress First Aid Program in the Fire Service

Journal of MultiDisciplinary Evaluation
Background: Behavioral health is a critical issue in the fire service, with firefighters facing high rates of depression, PTSD, and substance misuse due to repeated trauma exposure.
Brittany S. Hollerbach, Derrick Edwards, Nattinee Jitnarin, Gary Krichbaum, Frank Leeb, Patricia Watson, Richard Gist, sar Jahnke   +7 more
doaj  

The first 7 years of the metropolitan fire brigade emergency responder program – an overview of incidents attended

, 2010
Malcolm J Boyle1, Brett Williams1, Colin Bibby2, Allan Morton2, Chris Huggins11Department of Community Emergency Health and Paramedic Practice, Monash University, Frankston, Victoria, Australia; 2Emergency Medical Services, Metropolitan Fire and ...
et al, Malcolm J Boyle, Brett Williams, Colin Bibby   +3 more
core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

First Responder System and its Implementation in the Olomouc Region

, 2023
Tématem diplomové práce je First Responder systém a jeho zavádění v Olomouckém kraji. Práce je rozdělena na dvě části. Část teoretickou a část praktickou.
Fischer, Ivo
core   +2 more sources

Near-Peer Emergency Medicine for Medical Students in Port-au-Prince, Haiti: An Example of Rethinking Global Health Interventions in Developing Countries

Annals of Global Health, 2015
Background: During a 3-year time frame, a partnership between medical trainees in Haiti and the United States was forged with the objective of implementing an emergency response skills curriculum at a medical school in Port-au-Prince.
Christian A. Pean, Keithara Davis, Robert Merrill, Brett Marinelli, Allison Lockwood, Zara Mathews, Reuben J. Strayer, Geneviéve Poitevien, Jennifer Galjour   +8 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The Gendered Role of Resilience in First Responders in South Africa

Sexes
First responders are routinely exposed to potentially traumatic events and occupational stress, placing them at heightened risk for mental health difficulties.
Anita Padmanabhanunni, Tyrone B. Pretorius   +1 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source