Results 111 to 120 of about 13,471,873 (289)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Drones as First Responders [PDF]
With the demand for law and order to match the growing complexities of lawlessness, law enforcement has had to adapt to the ever-rising surge of danger by embracing innovative strategies and technologies, which provide the edge of today's first ...
Guidry, Kent
core +2 more sources
RELIEF 12-03 Draft Report [PDF]
, 2012 SUMMARY: The eleventh event of the Research and Experimentation for Local and International First Responders (RELIEF) projects took place from 21-23 May 2012 at the National Defense University in Washington, DC.
Bendett, Sam +2 more
core +1 more source
Identifying First Responders Information Needs
, 2019 At the onset of an indoor fire emergency, the availability of the information becomes critical due to the chaotic situation at the emergency site. Moreover, if information is lacking, not shared, or responders are too overloaded to acknowledge it, lives ...
Tina Comes +2 more
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
First Responders - Get Vaccinated [PDF]
, 2013 Brochure discussing importance of first responders to be current on vaccinations and advises taking advantage of the Texas Immunization ...
Texas. Department of State Health Services.
core
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source