Results 131 to 140 of about 14,718,934 (295)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Using the disperse system formalism, DSF, to determine the first two classes of complex suspensions

, 2022
The "disperse system formalism" (DSF) can be used to describe the structure of physical and chemical systems at any scale. It is particularly useful for describing the microstructure of colloidal systems that are ubiquitous in food. Adapting a computer program that was already used for the study of complex gels, the whole set of possible suspensions ...
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Chaotic Dynamics Analysis and FPGA Implementation Based on Gauss Legendre Integral

Mathematics
In this paper, we first design the corresponding integration algorithm and matlab program according to the Gauss–Legendre integration principle. Then, we select the Lorenz system, the Duffing system, the hidden attractor chaotic system and the Multi-wing
Li Wen, Li Cui, Hairong Lin, Fei Yu
doaj   +1 more source

How to use the first and second order sensitivities of steady-state solutions to water distribution systems

A hydraulic model can be of considerable benefit to those responsible for the design and operation of drinking water systems. In the contemporary era, it is imperative that water distribution systems are operated in a more sober manner, in a sustainable and resilient fashion, to combat the effects of global warming and to mitigate natural and ...
Piller, Olivier, Elhay, Sylvan, Deuerlein, Jochen, Simpson, Angus   +3 more
openaire   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Risks associated with a double-cropping production system - a case study in southern Brazil

Scientia Agricola
: This study assessed the risk exposure of the production system of a typical farm in southern Brazil. Five possible production systems were analyzed, combining three crops (soybeans, corn seasons and wheat) in different crop-year combinations, for ...
Mauro Osaki, Lucilio Rogerio Aparecido Alves, Fabio Francisco Lima, Renato Garcia Ribeiro, Geraldo Sant'Ana de Camargo Barros   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source