Results 91 to 100 of about 351,972 (313)

Fertility and early pregnancy outcomes after conservative treatment for cervical intraepithelial neoplasia [PDF]

, 2015
BACKGROUND: Cervical intra-epithelial neoplasia (CIN) typically occurs in young women of reproductive age. Although several studies have reported the impact that cervical conservative treatment may have on obstetric outcomes, there is much less evidence
Acharya, Albrechtsen, Anderson, Arbyn, Arbyn, Arbyn, Arbyn, Armarnik, Begg, Berretta, Bigrigg, Blomfield, Braet, Bruinsma, Bruinsma, Buller, Castanon, Castanon, Chew, Cochran, Conner, Cruickshank, Deeks, Dersimonian, Egger, Ferenczy, Forsmo, Founta, Frega, Gordon, GRADE Working Group 2004 GRADE Working Group, Haffenden, Hagen, Hammond, Heinonen, Higgins, Holmes, Holmes, Human Microbiome Project Consortium, Jakobsson, Jiménez, Jones, Kalliala, Kalliala, Keijser, Kennedy, Khalid, Kitchener, Kuoppala, Kyrgiou, Kyrgiou, Kyrgiou, Kyrgiou, Kyrgiou, Larsson, Li, Luesley, Macvicar, Martin-Hirsch, Mathevet, Mazouni, Michelin, Moher, NHS Cervical Screening Programme, Nicholson, Noehr, Nuovo, Paraskevaidis, Paraskevaidis, Paraskevaidis, Phadnis, Philipp, Prendiville, Quinn, Raio, Ravel, Sagot, Shanbhag, Sjøborg, Soutter, Spitzer, Spracklen, Steichen, Strander, Stroup, Suarez, Tan, Turlington, Vijver, Weber   +89 more
core   +1 more source

Population pharmacokinetic modelling of amoxicillin in human breast milk—A contribution from the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Aims Amoxicillin, a widely used β‐lactam antibiotic, requires improved pharmacokinetic characterization during breastfeeding. This study used a population pharmacokinetic (PopPK) approach to model amoxicillin concentrations in breast milk, identify variability sources and estimate infant exposure, applying worst‐case scenarios.
Sarah Baklouti, Virginie Rigourd, Alice Panchaud, Hedvig Nordeng, Karel Allegaert, Pieter Annaert, Miao‐Chan Huang, Anaelle Monfort, Monia Guidi, Peggy Gandia   +9 more
wiley   +1 more source

Evaluation of the Relationship between Fetal Neck Fold and Diagnosis of Turner Syndrome in the First Trimester of Pregnancy

Armaghane Danesh Bimonthly Journal, 2020
Background & aim: Children with various anomalies have economic and emotional burden on the family and society. Early detection of congenital anomalies early in pregnancy and its termination can prevent the birth of a disabled baby.
R Armand, M Harfsheno, M Barati
doaj  

Unintended Pregnancy And Induced Abortion In Mexico: Causes and Consequences [PDF]

, 2013
Examining the hidden and stigmatized practice of induced abortion is very hard to do. Throughout the Mexican Republic's 31 states, induced abortion is highly restricted.
Deirdre Wulf, Fatima Juarez, Isaac Maddow-Zimet, Susheela Singh   +3 more
core  

Stimulation of hCG protein and mRNA in first trimester villous cytotrophoblast cells in vitro by glycodelin A [PDF]

, 2005
Aim: Human chorionic gonadotropin (hCG) is produced by fetal trophoblast cells and secreted into maternal circulation mainly in the first trimester of pregnancy.
Albanese, Bergemann, Boime, Bonduelle, Cole, Hammer, Heffner, Jeschke, Julkunen, Julkunen, Kubota, Laird, Laird, Maston, Okamoto, Pestell, Pierro, Pockley, Pockley, Seppala   +19 more
core   +1 more source

Tacrolimus exposure during pregnancy in kidney and liver transplantation recipients: A comparison between whole blood and plasma concentration‐to‐dose ratios

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tacrolimus monitoring is generally performed in whole blood (WB). Most (>85%) of circulating tacrolimus is bound to red blood cells. During pregnancy, WB monitoring might be suboptimal because of physiological changes including increased plasma volume and decreased haematocrit.
Jildau R. Meinderts, Paola Mian, Frederike G. I. van Vilsteren, Karien M. H. van de Wetering, Jelmer R. Prins, Stefan P. Berger, Daan J. Touw, Margriet F. C. de Jong   +7 more
wiley   +1 more source

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source

Utility of first trimester obstetric ultrasonography before 13 weeks of gestation: a retrospective study

The Pan African Medical Journal, 2017
INTRODUCTION: first trimester pregnancy is defined as twelve weeks after the last menstrual period. Ultrasonography has revolutionized validation and management of first trimester pregnancies.
Felix Uduma Uduma, Anelkan Abaslattai, Dianabasi Udoete Eduwem, Morgan Ekanem, Philip Chinedu Okere   +4 more
doaj   +1 more source

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

Increased dietary protein in the second trimester of gestation increases live weight gain and carcass composition in weaner calves to 6 months of age [PDF]

, 2017
Genetically similar nulliparous Polled Hereford heifers from a closed pedigree herd were used to evaluate the effects of dietary protein during the first and second trimester of gestation upon fetal, placental and postnatal growth.
Baur, Bell, Brameld, Breier, C. Rutland, Cafe, Copping, Costello, Dunlap, Florini, G.G. Miguel-Pacheco, Gagniere, Gerrard, Greenwood, Greenwood, Hernandez-Medrano, Hopkins, Johnson, Klagsbrun, L. Knott, L.D. Curtain, Liu, Long, Lund-Larsen, Martin, Micke, Micke, Micke, Micke, Micke, Micke, N.J. Phillips, Norman, Oksbjerg, Oliver, Perry, Perry, Quigley, Reynolds, Robelin, Roberts, S.T. Norman, Shimada, Sullivan, Sullivan, Sullivan, Summers, Symonds, Symonds, Talbot, Tong, V.E.A. Perry, Vonnahme, Weibel, Wooding, Zhu   +55 more
core   +2 more sources