Results 51 to 60 of about 234,929 (313)

Identification of novel first-trimester serum biomarkers for early prediction of preeclampsia

Journal of Translational Medicine, 2023
Background Preeclampsia (PE) is a leading cause of maternal and perinatal mortality and morbidity worldwide, but effective early prediction remains a challenge due to the lack of reliable biomarkers.
Mingxi Liu, Yue Niu, Kongyang Ma, Peter C. K. Leung, Zi-Jiang Chen, Daimin Wei, Yan Li   +6 more
doaj   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Assessment of Cyclophilin A levels in early and late pregnancy among women with preeclampsia

Frontiers in Physiology
BackgroundPre-eclampsia is one of the leading causes of maternal-fetal morbidity. Cyclophilin A, which plays a role in inflammation and vascular dysfunction, may contribute to the pathogenesis of pre-eclampsia; however, trimester-specific levels have not
Neset Gumusburun, Selim Gulucu, Sebahattin Celik, Sercan Serin   +3 more
doaj   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Screening for aneuploidies by maternal age, fetal nuchal translucency and maternal serum biochemistry at 11-13+6 gestational weeks [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2012
Introduction. Aneuploidies are the major cause of perinatal death and early psychophysical disorders. Objective. In this study, we analyzed detection and false-positive rates of screening for aneuploidies in the first trimester by the combination of ...
Karadžov-Orlić Nataša, Egić Amira, Filimonović Dejan, Marinković Maja, Damnjanović-Pažin Barbara, Milovanović Zagorka, Joksić Ivana, Branković Snežana, Lukić Relja, Mandić Vesna, Cerović Nikola, Mojović Donka, Plamenac Sanja, Stanković Minja, Maglić Dragana, Miković Željko   +15 more
doaj   +1 more source

Accuracy of circulating adiponectin for predicting gestational diabetes : a systematic review and meta-analysis [PDF]

, 2016
Aims/hypothesis Universal screening for gestational diabetes mellitus (GDM) has not been implemented, and this has had substantial clinical implications. Biomarker-directed targeted screening might be feasible.
Kelsey, Tom, Stamatina Iliodromiti, Nelson, Scott M., Iliodromiti, S, Sattar, N, Thomas W. Kelsey, Sattar, Naveed, Kelsey, TW, Robert S. Lindsay, Sassarini, J, Scott M. Nelson, Jennifer Sassarini, Sassarini, Jennifer, Naveed Sattar, Lindsay, Robert S., Nelson, SM, Iliodromiti, Stamatina, Kelsey, Thomas W., Lindsay, R, Nelson, S, Lindsay, RS   +20 more
core   +1 more source

First-trimester biomarkers and ultrasound biometries in relation to growth discordance in monochorionic diamniotic twins

, 2023
Objective: The aim of this study was to investigate the association and predictive value between intertwin discordance in first trimester biometries crown-rump length (CRL) and nuchal translucency (NT), and the first trimester biochemical markers PAPP-A ...
Charlotte Kvist Ekelund (10885236), Frederikke Bang Løppke (14763228), Katrine Vasehus Schou (14763231), Ann Tabor (384342), Line Rode (8364912), Karin Sundberg (14763234)   +5 more
core   +1 more source

STAID: A Self‐Refining Deep Learning Framework for Spatial Cell‐Type Deconvolution with Biologically Informed Modeling

Advanced Science, EarlyView.
STAID is a unified deep learning framework that couples iterative pseudo‐spot refinement with neural network training through a feedback loop and exploits gene co‐expression information to model higher‐order interactions, achieving accurate and robust cell‐type deconvolution in spatial transcriptomics.
Jixin Liu, Shuli Sun, Zhengliang Lv, Xinyu Liu, Yihua Wang, Bingqiang Liu   +5 more
wiley   +1 more source

First-trimester metabolomic prediction of stillbirth

, 2018
Background: Stillbirth remains a major problem in both developing and developed countries. Omics evaluation of stillbirth has been highlighted as a top research priority.
Chiao-Li Tseng (1802626), Mark Redman (5432642), Nan Wang (21935), Ray O. Bahado-Singh (804903), Argyro Syngelaki (509771), Onur Turkoglu (804908), David S. Wishart (5821), BeomSoo Han (4139458), Dev Maulik (3986477), Kypros H. Nicolaides (222253), Trent C. Bjorndahl (453983), Rupsari Mandal (3089097), Liang Li (46069), Edison Dong (229888), Amna Zeb (2734900)   +14 more
core   +1 more source

Assessing the Impact of Promotions on Consumer Purchasing Behavior During Crises

Agribusiness, EarlyView.
ABSTRACT Understanding how households modify their food expenditure decisions during times of crisis is essential because consumer purchasing behavior frequently changes during these times. This study looks at these behavioral shifts during the COVID‐19 pandemic, concentrating on how price sensitivity and response to sales promotions changed over the ...
Wafa Mehaba, José María Gil
wiley   +1 more source