Results 161 to 170 of about 2,310,292 (345)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

The United States policy in the First World War

open access: yesАмериканська історія і політика, 2017
On the anniversary of the USA entrance to the WWI, let us remind its circumstances. Back in the 19th century, isolationism dominated in the USA despite the expansion іn the Pacific and Caribean basins.
Mykhailo Kirsenko, Tetiana Balabushevych
doaj  

MILITARY BURIALS OF THE FIRST WORLD WAR IN IVANO-FRANKIVSK

open access: bronze, 2023
Yelyzaveta KORZHUK   +1 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

The Costs of Doing Hard Time: A penitentiary-based regional price index for Canada, 1883-1923 [PDF]

open access: yes
We construct consumer price indices for Canada, mainly based on the expenditure records of Canada’s federal penitentiaries. Regional price variation was much greater in Canada in the late nineteenth century than in the northern U.S.
Chris Minns, Mary Mackinnon
core   +3 more sources

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