Results 161 to 170 of about 2,260,299 (337)

Close Fire Support: Sexton Self-Propelled Guns of the 23rd Field Regiment, 1942–1945 [PDF]

open access: yes, 2012
On the battlefields of the First World War, initially successful attacks all too often ended in failure because artillery weapons could not be moved up quickly enough to support assault infantry at the sharp end of the fight.
Iarocci, Andrew
core   +1 more source

The First World War

open access: yes, 1991
Abstract This is a completely new interpretation of the First World War. Dr Offer weaves together the economic and social history of the English-speaking world, the Pacific Basin, and Germany, with the development of food production and consumption.
openaire   +2 more sources

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

open access: yesMolecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková   +14 more
wiley   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

The Costs of Doing Hard Time: A penitentiary-based regional price index for Canada, 1883-1923 [PDF]

open access: yes
We construct consumer price indices for Canada, mainly based on the expenditure records of Canada’s federal penitentiaries. Regional price variation was much greater in Canada in the late nineteenth century than in the northern U.S.
Chris Minns, Mary Mackinnon
core   +3 more sources

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

open access: yesMolecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez   +5 more
wiley   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee   +9 more
wiley   +1 more source

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