MARPLE: A Proximity‐Triggered CRISPR‐Cas13 Platform for Ultrasensitive Antibody Detection
Advanced Science, EarlyView.MARPLE is a modular CRISPR‐Cas13 immunoassay that uses antibody‐induced proximity to trigger a toehold‐exchange reaction, releasing an RNA activator for Cas13. This one‐pot, isothermal architecture enables ultrasensitive (femtomolar) and highly specific detection of diverse antibodies, including therapeutic, pathogen‐specific, and cancer‐associated ...
Elena Spezzani +6 more
wiley +1 more source
Fiscal Autonomy and EU Structural Funds The Case of the Italian Regional Income Tax System
, 2018 C. D. Bo
semanticscholar +2 more sources
Municipal Finance in Poland, the Slovak Republic, the Czech Republic and Hungary: Institutional Framework and Recent Development [PDF]
The recent process of political and economic transformation in eastern European countries has not only contributed to the decentralisation of political structure but also significantly enhanced the fiscal autonomy of municipalities in these countries. In
Chang Woon Nam, Rüdiger Parsche
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Advanced Science, EarlyView.Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang +7 more
wiley +1 more source
Analysis of Multi-Domain Factors Influencing Mental Health and Suicide: A Comparative Study of Urban and Rural Areas at City, County, and District Levels in Korea. [PDF]
J Korean Med SciKim C +7 more
europepmc +1 more source
The fiscal autonomy of French Polynesia
, 2015 Sur le papier, l'autonomie de la Polynésie française ne fait aucun doute. Elle est même manifeste sur le plan juridique depuis le statut de 1977 qui donne à la Polynésie la compétence de principe. Par la révision constitutionnelle du 28 mars 2003, le terme a fait son entrée dans le texte suprême. Quant à la loi organique n° 2004-192 du 27 février 2004,
openaire +1 more source
Basic Strategies For The Role Of Indonesian Central-local Government In Poverty Alleviation Programs [PDF]
One consequence of Indonesian fiscal decentralization and regional autonomy is that local governments now have more responsibility to more participate in poverty alleviation programs.
Kodrat Wibowo
core
Advanced Science, EarlyView.In the unmethylated state, TEAD forms stable, repressive condensates that sequester the osteogenic master regulator RUNX2. Arginine methylation of TEAD at R55 acts as a molecular brake, dissolving these condensates to release RUNX2 and activate the osteogenic program.
Lei Cao +6 more
wiley +1 more source
Fiscal stress as a catalyst for public service provision in China: evidence from the VAT reform. [PDF]
Front SociolCai X, Zhang B, Yang J.
europepmc +1 more source
Why do differences in the degree of fiscal decentralization endure? [PDF]
A notable difference between the U.S. and many countries in Europe is in the degree of fiscal decentralization. Regional (and local) governments in the U.S. have significant autonomy in setting their own taxes and determining how to spend their revenues.
Teresa Garcia-Milà +2 more
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